Anti-ErbB2 Polyclonal Antibody
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Synonyms:
cerbB2
Entrez Gene ID:
(Human) 2064
UniProt ID:
P04626
| Details | |
| Host / Isotype: | Chicken |
| Class: | Polyclonal |
| Type: | Antibody |
| Species Reactivity: | Human (Hu) Canine (Ca) Feline (Fe) |
| Immunogen: | Human Her2. |
| Ordering Information | ||||
| Pierce Anti-ErbB2 Polyclonal Antibody | ||||
| Product Number | Pkg. Size | Price | Purchase | |
| PY-10256 | 100 µg | $285.00 | ||
This product is not available outside of the U.S.
| Storage: | -20º C, Avoid Freeze/Thaw Cycles |
| Form: | 100 µg of affinity purified antibody in PBS buffer in lyophilized powder. Redissolving the powder with 100µL sterile water will restore the original concentration to 1mg/mL. |
| Applications | Dilution |
| Western Blot (WB) | 1:2,000 |
| Product Specific Information |
| PY-10256 detects Her2 in human, canine and feline samples. PY-10256 has been successfully used in Western blot procedures. The PY-10256 immunogen is human Her2. Figure 1 illustrates immunohistochemical staining of ErbB2 in oral cancer epithelium by using antibody PY-10256. |
| General Information |
| ErbB2 (also known as Her2 or neu) is a 185 kDa transmembrane receptor tyrosine kinase from the EGFR family that acts to regulate a variety of biological responses including cell growth, differentiation, and tissue development. Ligand binding to the extracellular domain, or overexpression of the receptor leads to phosphorylation on several tyrosine residues within the cytoplasmic domain, and activation. Overexpression or abnormal activation of ErbB2 has been found in a variety of tumors including brain, breast, lung and skin cancer. Autophosphorylation of tyrosine 1139 on ErbB2 allows binding of Grb2 and the Src SH2 domain, which allows activation of the Ras, Raf, ERK1&2 and JAK/STAT signaling pathways, respectively. |
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Immunohistochemistry with anti-ErbB2 Polyclonal Antibody (PY-10256)
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(This product is for In Vitro experimental use only.)
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PO
Box 117, Rockford, IL 61105 USA |
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