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PEROXIREDOXIN 4 ANTIBODIES > PEROXIREDOXIN 4 POLYCLONAL ANTIBODY PA3-753
Anti-Peroxiredoxin 4 Polyclonal Antibody
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Synonyms:
Prx 4
Entrez Gene ID:
(Human) 10549
UniProt ID:
Q13162
| Details | |
| Host / Isotype: | Rabbit |
| Class: | Polyclonal |
| Type: | Antibody |
| Species Reactivity: | Human (Hu) |
| Immunogen: | Purified human recombinant Peroxiredoxin 4. |
| Ordering Information | ||||
| Pierce Anti-Peroxiredoxin 4 Polyclonal Antibody | ||||
| Product Number | Pkg. Size | Price | Purchase | |
| PA3-753 | 100 µl | $350.00 | ||
| Storage: | -20º C, Avoid Freeze/Thaw Cycles |
| Form: | 100 ul of antiserum containing 0.05% sodium azide. |
| Applications | Dilution |
| Immunocytochemistry (ICC) | 1:500 |
| Western Blot (WB) | 1:10,000 |
| Product Specific Information |
| PA3-753 detects Peroxiredoxin 4 protein in human samples. This antibody is specific for Prx 4 and shows no cross-reactivity with other Prx isoforms. PA3-753 has successfully been used in Western blot and immunocytochemistry procedures. By Western blot, this antibody detects an ~23 kDa and ~20 kDa protein representing pro-Prx 4 and mature Prx 4, respectively, in human PC3 cell lysate. The PA3-753 antigen is purified human recombinant Prx 4 from K562 cells. Figure 1 shows staining of Prx 4 in TSU-Pr1 cells using PA3-753. |
| General Information |
| The peroxiredoxin (Prdx, Prx, or Trx-Px) family of enzymes is a recently identified family of peroxidases found in free-living organisms. The six known isoforms (Prx1-6) play an important role in protecting lipids, enzymes and DNA against peroxides, such as hydrogen peroxide. The ubiquitously expressed peroxiredoxins have also been shown to play a role in apoptosis and cell differentiation. This is acomplished by the active cysteine of Prx reducing peroxides, which is then converted into a transient cysteine sulfenic acid or cysteine sulfinic acid. If Prx protection is inadequate against peroxidases, the resulting protein and DNA damage may result in neurological disease such as Alzheimer’s or DNA damage leading to cancer. |
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Immunohistochemistry with anti-Peroxiredoxin 4 Polyclonal Antibody (PA3-753)
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| References: |
| Mol Med. 8(2):95-102, 2002 |
(This product is for In Vitro experimental use only.)
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