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Anti-Lubricin Polyclonal Antibody

Printable Datasheet

Details
Host / Isotype: Rabbit
Class: Polyclonal
Type: Antibody
Clone:
Label:
Species Reactivity: Human (Hu)
Immunogen: Synthetic peptide corresponding to residues I(19) Q Q V S S Q D L S(28)C of human Lubricin.
Applications Dilution
Western Blot (WB) 1 µg/ml
Ordering Information
Pierce Anti-Lubricin Polyclonal Antibody
Product Number Pkg Size Price


PA3-130 100 µg $354.00
Storage: -20º C, Avoid Freeze/Thaw Cycles
Form: 100 ug of affinity purified antibody (1mg/ml) in PBS containing 1mg/ml BSA and 0.05% sodium azide.


Product Specific Information General Information
PA3-130 detects lubricin in human samples.

PA3-130 has been successfully used in Western blot procedures. By Western blot, this antibody detects a ~64 kDa protein representing lubricin in human samples.

The PA3-130 immunogen is a synthetic peptide corresponding to residues I(19) Q Q V S S Q D L S(28)C of human Lubricin. This polyclonal antibody has been referred to as: JSCIQQ. This peptide (Cat. # PEP-288) is available for use in neutralization and control experiments.

Figure 1 illustrates Western blot detection of human recombinant lubricin using PA3-130.
Lubricin is a glycoprotein encoded by the PRG4 gene. It has been identified as a component of joint lubrication and synovial homeostasis by reducing friction in joints and preventing synovial cell overgrowth. It is a large, water soluble molecule that acts as a carrier for insoluble surface-active phospholipid (SAPL). Depletion of lubricin function has been associated with camptodactyly-arthropathy-coxa vara-pericarditis syndrome (CACP), an arthritic-like autosomal recessive disorder.
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References:

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Human Lubricin Protein (residues 19-28) Peptide (PEP-288)
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This product is for In Vitro experimental use only
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