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Anti-PAC1 Polyclonal Antibody

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Synonyms:
Pituitary Adenylate Cyclase-activating peptide receptor,
Entrez Gene ID:
(Human) 117
UniProt ID:
P41586
Details
Host / Isotype: Rabbit
Class: Polyclonal
Type: Antibody
Species Reactivity: Human (Hu)
Immunogen: Synthetic peptide, KLH conjugated, corresponding to the residues L(506) S K S S S Q I R M S G L P A D N L A T(525) of human PAC1.
Ordering Information
Pierce Anti-PAC1 Polyclonal Antibody
Product Number Pkg. Size Price Purchase
PA3-115 100 µl $354.00


Storage: -20º C, Avoid Freeze/Thaw Cycles
Form: 100 ul of antiserum containing 0.05% sodium azide.


Applications Dilution
Immunocytochemistry (ICC) 1:1,000
Immunohistochemistry (Paraffin) (IHC (P)) 1:500
Western Blot (WB) 1:1,000
Product Specific Information
PA3-115 detects PAC1 in human samples.

PA3-115 has been successfully used in Western blot, immunocytochemistry and immunohistochemistry procedures. By Western blot, this antibody detects an ~40-60 kDa protein representing PAC1 in human samples. In immunohistochemistry, PAC1 immunoreactivity is predominantly localized to the plasma membrane.

PA3-115 immunogen is a synthetic peptide, KLH conjugated, corresponding to the residues L(506) S K S S S Q I R M S G L P A D N L A T(525) of human VPAC2 receptor.

Figure 1 shows Immunohistochemical staining of PAC1 in human myenteric ganglia cells of the small intestine using PA3-115.
General Information
The pituitary adenylate cyclase-activating peptide receptor (PAC1) is a member of a family of three G-protein coupled receptors which mediate VIP (vasoactive intestinal peptide) and PACAP (pituitary adenlyate cyclase activating peptide) function in a variety of tissues. PAC1 demonstrates a higher affinity for PACAP than VIP. Expression of the VIP and VACAP receptors has been linked to the presence of human tumors.
Immunohistochemistry with anti-PAC1 Polyclonal Antibody (PA3-115)
References:
Clinical Cancer Research Vol. 10, 8235–8242, December 15, 2004
(This product is for In Vitro experimental use only.)


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