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SOMATOSTATIN RECEPTOR 3 ANTIBODIES > SOMATOSTATIN RECEPTOR 3 POLYCLONAL ANTIBODY PA3-110
Anti-Somatostatin Receptor 3 Polyclonal Antibody
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Synonyms:
SSTR3
Entrez Gene ID:
(Human) 6753
UniProt ID:
P32745
| Details | |
| Host / Isotype: | Rabbit |
| Class: | Polyclonal |
| Type: | Antibody |
| Species Reactivity: | Human (Hu) |
| Immunogen: | Synthetic peptide corresponding to residues C Q(385) E R P P S R V A(393) of human SSTR3. |
| Ordering Information | ||||
| Pierce Anti-Somatostatin Receptor 3 Polyclonal Antibody | ||||
| Product Number | Pkg. Size | Price | Purchase | |
| PA3-110 | 100 µl | $354.00 | ||
| Storage: | -20º C, Avoid Freeze/Thaw Cycles |
| Form: | 100 ul of antisera containing 0.05% sodium azide. |
| Applications | Dilution |
| Immunocytochemistry (ICC) | 1:5000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:2500 |
| Western Blot (WB) | 1:5000 |
| Product Specific Information |
| PA3-110 detects the Somatostatin Receptor 3 in human samples. PA3-110 has been used successfully in Western blot, immunocytochemistry, and immunohistochemistry procedures. In Western blot analysis of SSTR3 transfected HEK-293 cells this antibody detects a ~60-70 kDa protein representing SSTR3. The PA3-110 immunogen is a synthetic peptide corresponding to residues C Q(385) E R P P S R V A(393) of human SSTR3. Figure 1 shows an immunohistochemical staining of SSTR3 in human pancreatic islands using PA3-110. |
| General Information |
| Expression of Somatostatin Receptor Type 3 (SSTR3) has been reported in brain, breast, eye, gastrointestinal tract, pancreas, and thyroid. G-protein Coupled Receptors (GPCRs) comprise one of the largest families of signaling molecules with more than a thousand members currently predicted to exist. All GPCRs share a structural motif consisting of seven membrane-spanning helices, and exist in both active and inactive forms. An array of activating ligands participate in the conformation of GPCRs which leads to signaling via G-proteins and downstream effectors. Ongoing studies have also shown the vast series of reactions which participate in the negative regulation of GPCRs. This "turn-off" activity has tremendous implications for the physiological action of the cell, and continues to drive pharmacological research for new drug candidates. Two blockbuster drugs which have been developed as GPCR-targeted pharmaceuticals are Zyprexa (Eli Lilly) and Claritin (Schering-Plough) which have multi-billion dollar shares of the mental health and allergy markets, respectively. |
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Immunohistochemistry with anti-Somatostatin Receptor 3 Polyclonal Antibody (PA3-110)
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(This product is for In Vitro experimental use only.)
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