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SOMATOSTATIN RECEPTOR 1 ANTIBODIES > SOMATOSTATIN RECEPTOR 1 POLYCLONAL ANTIBODY PA3-108
Anti-Somatostatin Receptor 1 Polyclonal Antibody
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Synonyms:
SSTR1
Entrez Gene ID:
(Human) 6751
UniProt ID:
P30872
| Details | |
| Host / Isotype: | Rabbit |
| Class: | Polyclonal |
| Type: | Antibody |
| Species Reactivity: | Human (Hu) |
| Immunogen: | Synthetic peptide corresponding to residues C(380) R N G T C T S R I T T L(391) of human SSTR1. |
| Ordering Information | ||||
| Pierce Anti-Somatostatin Receptor 1 Polyclonal Antibody | ||||
| Product Number | Pkg. Size | Price | Purchase | |
| PA3-108 | 100 µl | $350.00 | ||
| Storage: | -20º C, Avoid Freeze/Thaw Cycles |
| Form: | 100 ul of antisera containing 0.05% sodium azide. |
| Applications | Dilution |
| Immunocytochemistry (ICC) | 1:5000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:2500 |
| Western Blot (WB) | 1:5000 |
| Product Specific Information |
| PA3-108 detects the Somatostatin Receptor 1 in human samples. PA3-108 has been used successfully in Western blot, immunocytochemistry, and immunohistochemistry procedures. In Western blot analysis of SSTR1 transfected HEK-293 cells this antibody detects a ~52-63 kDa protein representing SSTR1. The PA3-108 immunogen is a synthetic peptide corresponding to residues C(380) R N G T C T S R I T T L(391) of human SSTR1. Figure 1 shows an immunohistochemical staining of SSTR1 in human gastric mucosa using PA3-108. |
| General Information |
| The Somatostatin Receptor Type 1 (SSTR1) has been reported at highest levels in the jejunum and stomach. In addition, SSTR1 has been shown to be expressed in adrenal, brain, eye, and panreas. ESTs have been isolated from normal placenta and colon cancer libraries. G-protein Coupled Receptors (GPCRs) comprise one of the largest families of signaling molecules with more than a thousand members currently predicted to exist. All GPCRs share a structural motif consisting of seven membrane-spanning helices, and exist in both active and inactive forms. An array of activating ligands participate in the conformation of GPCRs which leads to signaling via G-proteins and downstream effectors. Ongoing studies have also shown the vast series of reactions which participate in the negative regulation of GPCRs. This "turn-off" activity has tremendous implications for the physiological action of the cell, and continues to drive pharmacological research for new drug candidates. Two blockbuster drugs which have been developed as GPCR-targeted pharmaceuticals are Zyprexa (Eli Lilly) and Claritin (Schering-Plough) which have multi-billion dollar shares of the mental health and allergy markets, respectively. |
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Immunohistochemistry with anti-Somatostatin Receptor 1 Polyclonal Antibody (PA3-108)
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(This product is for In Vitro experimental use only.)
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