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VITAMIN D RECEPTOR ANTIBODIES > VITAMIN D RECEPTOR POLYCLONAL ANTIBODY PA1-9116
Anti-Vitamin D Receptor Polyclonal Antibody
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Synonyms:
VDR; vitamin D (1,25- dihydroxyvitamin D3) receptor ; HGNC:12679; NR1I1; vitamin D (1,25-dihydroxyvitamin D3) receptor
Entrez Gene ID:
(Human) 7421
UniProt ID:
P11473
| Details | |
| Host / Isotype: | Goat |
| Class: | Polyclonal |
| Type: | Antibody |
| Species Reactivity: | Human (Hu) |
| Immunogen: | Internal sequence corresponding to amino acids CGNQDYKYRVSD. |
| Ordering Information | ||||
| Pierce Anti-Vitamin D Receptor Polyclonal Antibody | ||||
| Product Number | Pkg. Size | Price | Purchase | |
| PA1-9116 | 100 ug | $268.00 | ||
| Storage: | 4º C |
| Form: | 100 µg of affinity purified antibody (0.5 mg/ml) in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. |
| Applications | Dilution |
| ELISA (ELISA) | 1:16000 |
| Western Blot (WB ) | 0.3-1.0 µg/ml |
| Product Specific Information |
| PA1-9116 detects VDR in human samples, expected to react with mouse, rat, and dog due to sequence similarity. PA1-9116 has been successfully used in Western blot and peptide ELISA procedures. PA1-9116 immunogen is an internal sequence of the VDR protein corresponding to amino acids CGNQDYKYRVSD. For long term storage keep aliquots at -20ºC. Store no longer than 12 months at 4ºC. Figure 1 illustrates Western blot detection of VDR in human brain lysate using PA1-9116. |
| General Information |
| Steroid receptors are ligand-dependent intracellular proteins that stimulate transcription of specific genes by binding to specific DNA sequences following activation by the appropriate hormone. The 1,25-dihydroxy-vitamin D3 receptor (VDR) belongs to the superfamily of steroid hormone receptors which includes estrogen, progesterone, glucocorticoid, androgen, and thyroid hormone receptors. Vitamin D modulates calcium and phosphorus homeostasis, bone remodeling, cell growth regulation, and differentiation. Studies have found VDR in the intestine, bone, kidney, epidermis, and cells of the endocrine immune system. Repression of T-cell proliferation and interleukin-2 (IL-2) gene expresion, for example, occurs when VDR binds within the IL-2 enhancer. Formation of VDR/retinoic X receptor (RXR) heterodimers in the presence of intracellular 1,25(OH)2D3 has been shown to interfere with assembly of nuclear factor of activated T-cells (NFATp)/Fos/Jun/DNA complex and subsequent IL-2 gene transcription. |
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with anti-Vitamin D Receptor Polyclonal Antibody (PA1-9116)
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(This product is for In Vitro experimental use only.)
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Box 117, Rockford, IL 61105 USA |
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