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Anti-GRB2 Polyclonal Antibody

Printable Datasheet

Details
Host / Isotype: Goat
Class: Polyclonal
Type: Antibody
Clone:
Label:
Species Reactivity: Human (Hu)
Immunogen: Synthetic peptide corresponding to the C terminus amino acids PRNYVTPVNRNV.
Applications Dilution
Immunohistochemistry (Paraffin) (IHC (P)) 0.1-0.3 ug/ml
Western Blot (WB) 1-3 µg/ml
Ordering Information
Pierce Anti-GRB2 Polyclonal Antibody
Product Number Pkg Size Price


PA1-9051 100 ug $322.00
Storage: -20º C, Avoid Freeze/Thaw Cycles
Form: 100 µg of affinity purified antibody in 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin.


Product Specific Information General Information
PA1-9051 detects GRB2 in human samples.

PA1-9051 has been successfully used in Western blot and immunohistochemistry (paraffin-embedded sections) procedures.

PA1-9051 immunogen is a synthetic peptide corresponding to the C terminus of GRB2, amino acids PRNYVTPVNRNV.

Figure 1 illustrates Western blot detection of GRB2 in Jurkat lysate using PA1-9051.

Figure 2 illustrates specific staining of paraffin embedded human tonsil using PA1-9051.
GRB 2 protein contains one SH2 domain flanked on both sides by an SH3 domain. In response to EGF, GRB 2 binds, through its SH3 domains, to the guanine nucleotide exchange factor, Sos. The GRB 2 - Sos complex then binds the EGF receptor. These interactions play a critical role in the activation of the p21 ras signalling pathway.
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References:

No references for this product.

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