Anti-GRB2 Polyclonal Antibody
| Host / Isotype: |
Goat |
| Class: |
Polyclonal |
| Type: |
Antibody |
| Clone: |
|
| Label: |
|
| Species Reactivity: |
Human (Hu) |
| Immunogen: |
Synthetic peptide corresponding to the C terminus amino acids PRNYVTPVNRNV. |
|
| Immunohistochemistry (Paraffin) (IHC (P)) |
0.1-0.3 ug/ml |
| Western Blot (WB) |
1-3 µg/ml |
| Pierce Anti-GRB2 Polyclonal Antibody |
|
| Product Number |
Pkg Size |
Price |
|
|
| PA1-9051 |
100 ug |
$322.00 |
|
|
|
|
| Storage: |
-20º C, Avoid Freeze/Thaw Cycles |
| Form: |
100 µg of affinity purified antibody in 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. |
PA1-9051 detects GRB2 in human samples.
PA1-9051 has been successfully used in Western blot and immunohistochemistry (paraffin-embedded sections) procedures.
PA1-9051 immunogen is a synthetic peptide corresponding to the C terminus of GRB2, amino acids PRNYVTPVNRNV.
Figure 1 illustrates Western blot detection of GRB2 in Jurkat lysate using PA1-9051.
Figure 2 illustrates specific staining of paraffin embedded human tonsil using PA1-9051. |
GRB 2 protein contains one SH2 domain flanked on both sides by an SH3 domain. In response to EGF, GRB 2 binds, through its SH3 domains, to the guanine nucleotide exchange factor, Sos. The GRB 2 - Sos complex then binds the EGF receptor. These interactions play a critical role in the activation of the p21 ras signalling pathway. |
No references for this product. |
This product is for In Vitro experimental use only
Printable Datasheet
