Anti-CDKN2A Polyclonal Antibody
| Host / Isotype: |
Goat |
| Class: |
Polyclonal |
| Type: |
Antibody |
| Clone: |
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| Label: |
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| Species Reactivity: |
Human (Hu) |
| Immunogen: |
Synthetic peptide corresponding to the C terminus amino acids HARIDAAEGPSDIPD. |
|
| Western Blot (WB) |
0.1-1 µg/ml |
| Pierce Anti-CDKN2A Polyclonal Antibody |
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| Product Number |
Pkg Size |
Price |
|
|
| PA1-9025 |
100 ug |
$268.00 |
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| Storage: |
-20º C, Avoid Freeze/Thaw Cycles |
| Form: |
100 µg of affinity purified antibody (0.5 mg/ml) in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. |
PA1-9025 detects p16INK4a in human samples.
PA1-9025 has been successfully used in Western blot procedures.
PA1-9025 immunogen is a synthetic peptide corresponding to the C terminus of p16INK4a, amino acids HARIDAAEGPSDIPD.
Figure 1 illustrates Western blot detection of p16INK4a in heLa Lysate using PA1-9025. |
The four known 15-to 19 kDa INK4 proteins (p15INK4b, p16INK4a, p18INK4c andp19INK4d) bind and inhibit CDK4 and CDK6 but not other CDKs, including cyclin E-Cdk2, cyclin A-Cdk2 and cyclin B-Cdk1. Like the three D-type cyclins, the INK4 genes are expressed in distinct tissue-specific patterns, suggesting that they are not strictly redundant.5 p18INK4c is expressed during G1 to S transition in the eukaryotic cell division cycle. It is maximally induced as cells enter S-phase. The availability of a monoclonal antibody reacting specifically with p18INK4c enables the subcellular detection and localization of p18INK4c and the measurement of relative differences in p18INK4c levels as a function of cell cycle phase. |
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No references for this product. |
This product is for In Vitro experimental use only
Printable Datasheet
