Anti-CDKN2A Polyclonal Antibody
Printable Datasheet
Synonyms:
CDKN2A; cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4) ; HGNC:1787; ARF; CDK4I; CDKN2; CMM2; INK4; INK4a; MLM; MTS1; TP16; p14; p
Entrez Gene ID:
(Human) 1029
UniProt ID:
P42771
| Details | |
| Host / Isotype: | Goat |
| Class: | Polyclonal |
| Type: | Antibody |
| Species Reactivity: | Human (Hu) |
| Immunogen: | Synthetic peptide corresponding to the C terminus amino acids HARIDAAEGPSDIPD. |
| Ordering Information | ||||
| Pierce Anti-CDKN2A Polyclonal Antibody | ||||
| Product Number | Pkg. Size | Price | Purchase | |
| PA1-9025 | 100 ug | $268.00 | ||
| Storage: | -20º C, Avoid Freeze/Thaw Cycles |
| Form: | 100 µg of affinity purified antibody (0.5 mg/ml) in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. |
| Applications | Dilution |
| ELISA (ELISA) | 1-32,000 |
| Western Blot (WB ) | 0.1-1 µg/ml |
| Product Specific Information |
| PA1-9025 detects p16INK4a in human samples. PA1-9025 has been successfully used in ELISA, and Western blot procedures. PA1-9025 immunogen is a synthetic peptide corresponding to the C terminus of p16INK4a, amino acids HARIDAAEGPSDIPD. Figure 1 illustrates Western blot detection of p16INK4a in heLa Lysate using PA1-9025. |
| General Information |
| This gene generates several transcript variants which differ in their first exons. At least three alternatively spliced variants encoding distinct proteins have been reported, two of which encode structurally related isoforms known to function as inhibitors of CDK4 kinase. The remaining transcript includes an alternate first exon located 20 Kb upstream of the remainder of the gene; this transcript contains an alternate open reading frame (ARF) that specifies a protein which is structurally unrelated to the products of the other variants. This ARF product functions as a stabilizer of the tumor suppressor protein p53 as it can interact with, and sequester, MDM1, a protein responsible for the degradation of p53. In spite of the structural and functional differences, the CDK inhibitor isoforms and the ARF product encoded by this gene, through the regulatory roles of CDK4 and p53 in cell cycle G1 progression, share a common functionality in cell cycle G1 control. This gene is frequently mutated or deleted in a wide variety of tumors, and is known to be an important tumor suppressor gene. |
(This product is for In Vitro experimental use only.)
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