Anti-APE1 Polyclonal Antibody
Printable Datasheet
Synonyms:
APEX; APEX1; APEX nuclease (multifunctional DNA repair enzyme); APE; APX; APE1; APEN; HAP1; REF1; REF-1; AP lyase; AP endonuclease class I; apurinic/a
Entrez Gene ID:
(Human) 328
UniProt ID:
P27695
| Details | |
| Host / Isotype: | Goat |
| Class: | Polyclonal |
| Type: | Antibody |
| Species Reactivity: | Human (Hu) |
| Immunogen: | Synthetic peptide corresponding to the N terminus amino acids PKRGKKGAVAEDGD. |
| Ordering Information | ||||
| Pierce Anti-APE1 Polyclonal Antibody | ||||
| Product Number | Pkg. Size | Price | Purchase | |
| PA1-9007 | 100 ug | $268.00 | ||
| Storage: | -20º C, Avoid Freeze/Thaw Cycles |
| Form: | 100 µg of affinity purified antibody in 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. |
| Applications | Dilution |
| Western Blot (WB ) | 0.2-1 µg/ml |
| Product Specific Information |
| PA1-9007 detects APEX1 in human samples. PA1-9007 has been successfully used in Western blot procedures. PA1-9007 immunogen is a synthetic peptide corresponding to the N terminus of APEX1, amino acids PKRGKKGAVAEDGD. Figure 1 illustrates Western blot detection of APEX1 in A431 lysate using PA1-9007. |
| General Information |
| Apurinic/apyrimidinic (AP) sites occur frequently in DNA molecules by spontaneous hydrolysis, by DNA damaging agents or by DNA glycosylases that remove specific abnormal bases. AP sites are pre-mutagenic lesions that can prevent normal DNA replication so the cell contains systems to identify and repair such sites. Class II AP endonucleases cleave the phosphodiester backbone 5' to the AP site. This gene encodes the major AP endonuclease in human cells. Splice variants have been found for this gene; all encode the same protein. |
(This product is for In Vitro experimental use only.)
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