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Anti-FOXO1 Polyclonal Antibody

Printable Datasheet

Details
Host / Isotype: Rabbit
Class: Polyclonal
Type: Antibody
Clone:
Label:
Species Reactivity: Rat (Rt)
Immunogen: Synthetic peptide corresponding to residues D(633) N V L P N Q S F P H S V K T(647) of human FOXO1a.
Applications Dilution
Western Blot (WB) 1:500
Ordering Information
Pierce Anti-FOXO1 Polyclonal Antibody
Product Number Pkg Size Price


PA1-804 100 µg $350.00
Storage: -20º C, Avoid Freeze/Thaw Cycles
Form: 100 ug of epitope affinity purified rabbit IgG (1 mg/ml) in PBS containing 1 mg/ml BSA and 0.05% sodium azide


Product Specific Information General Information
PA1-804 detects FoxO1a.

PA1- 804 has been successfully used in Western blot procedures. By Western blot this antibody detects a ~66 kDa protein representing FoxO1a in rat heart and lung protein extracts.

The PA1- 804 immunogen is a synthetic peptide corresponding to residues D(633) N V L P N Q S F P H S V K T(647) of human FOXO1a. This sequence is completely conserved in mouse and rat.

Fig. 1 shows a Western blot of FoxO1a in rat lung protein extract using PA1-804.
FoxO1A belongs to the forkhead family of transcription factors, which are involved in many biological processes and function under the control of the insulin signaling pathway. The mammalian DAF-16-like transcription factors, FoxO1A, FkhRL1, and AFX, function as key regulators of insulin signaling, cell cycle progression, and apoptosis downstream of phosphoinositide 3-kinase. Dysfunction in FoxO signaling has been linked to insulin resistance and type II diabetes. The FoxO1A gene is mapped to chromosome 13q14.
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References:

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