Anti-VAMP4 Polyclonal Antibody
| Host / Isotype: |
Rabbit |
| Class: |
Polyclonal |
| Type: |
Antibody |
| Clone: |
|
| Label: |
|
| Species Reactivity: |
Human (Hu) Murine (Ms) |
| Immunogen: |
Recombinant rat VAMP-4 protein. |
|
| Immunofluorescence (IF) |
10 ug/ml |
| Western Blot (WB) |
1 ug/ml |
| Pierce Anti-VAMP4 Polyclonal Antibody |
|
| Product Number |
Pkg Size |
Price |
|
|
| PA1-768 |
100 µg |
$350.00 |
|
|
|
|
| Storage: |
-20º C, Avoid Freeze/Thaw Cycles |
| Form: |
100 ug of epitope affinity purified IgG in PBS containing 1 mg/ml BSA and 0.05% sodium azide. |
PA1-768 detects VAMP-4 from human and mouse samples.
PA1-768 has been successfully used in Western blot and immunofluorescence procedures. By Western blot, this antibody detects an ~18 kDa protein representing VAMP-4 from PC3 cell extract. Immunofluorescent staining of VAMP-4 in CV-1 cells using PA1-768 results in a staining pattern consistent with VAMP-4 staining.
Immunofluorescence staining with this antibody requires saponin permeabilization.
The PA1-768 antigen is recombinant rat VAMP-4. |
The vesicle associated membrane proteins (VAMP) or synaptobrevins are calcium binding proteins specific to eukaryotes. VAMPs, along with synaptosomal associated protein of 25 kDa (SNAP-25) and syntaxin, form the core complex of soluble NSF attachment protein receptor (SNARE) proteins that interact with the soluble proteins N-ethylmaleimide-sensitive factor (NSF) and alpha-SNAP. These membrane associated proteins play a key role in the regulation of vesicle membrane fusion with the plasma membrane. The Clostridium tetani neurotoxin is a metalloprotease with specificity for VAMP. In Alzheimer’s disease, VAMP levels of all isoforms appear to be significantly lowered. |
This product is for In Vitro experimental use only
Printable Datasheet
