Anti-VAMP4 Polyclonal Antibody
Printable Datasheet
Synonyms:
Vesicle Associated Membrane Protein 4
Entrez Gene ID:
(Human) 8674, (Murine) 53330
UniProt ID:
O75379
| Details | |
| Host / Isotype: | Rabbit |
| Class: | Polyclonal |
| Type: | Antibody |
| Species Reactivity: | Human (Hu) Murine (Ms) |
| Immunogen: | Recombinant rat VAMP-4 protein. |
| Ordering Information | ||||
| Pierce Anti-VAMP4 Polyclonal Antibody | ||||
| Product Number | Pkg. Size | Price | Purchase | |
| PA1-768 | 100 µg | $350.00 | ||
| Storage: | -20º C, Avoid Freeze/Thaw Cycles |
| Form: | 100 ug of epitope affinity purified IgG in PBS containing 1 mg/ml BSA and 0.05% sodium azide. |
| Applications | Dilution |
| Immunofluorescence (IF) | 10 ug/ml |
| Western Blot (WB) | 1 ug/ml |
| Product Specific Information |
| PA1-768 detects VAMP-4 from human and mouse samples. PA1-768 has been successfully used in Western blot and immunofluorescence procedures. By Western blot, this antibody detects an ~18 kDa protein representing VAMP-4 from PC3 cell extract. Immunofluorescent staining of VAMP-4 in CV-1 cells using PA1-768 results in a staining pattern consistent with VAMP-4 staining. Immunofluorescence staining with this antibody requires saponin permeabilization. The PA1-768 antigen is recombinant rat VAMP-4. |
| General Information |
| The vesicle associated membrane proteins (VAMP) or synaptobrevins are calcium binding proteins specific to eukaryotes. VAMPs, along with synaptosomal associated protein of 25 kDa (SNAP-25) and syntaxin, form the core complex of soluble NSF attachment protein receptor (SNARE) proteins that interact with the soluble proteins N-ethylmaleimide-sensitive factor (NSF) and alpha-SNAP. These membrane associated proteins play a key role in the regulation of vesicle membrane fusion with the plasma membrane. The Clostridium tetani neurotoxin is a metalloprotease with specificity for VAMP. In Alzheimer’s disease, VAMP levels of all isoforms appear to be significantly lowered. |
| References: |
| Eur. J. Cell Biol., 81(5):273-280, 2002. |
(This product is for In Vitro experimental use only.)
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