Anti-VAMP2 Polyclonal Antibody
Printable Datasheet
Synonyms:
Vesicle Associated Membrane Protein 2, Synaptobrevin
Entrez Gene ID:
(Murine) 24803, (Murine) 22318
UniProt ID:
Q9WUW2
| Details | |
| Host / Isotype: | Rabbit |
| Class: | Polyclonal |
| Type: | Antibody |
| Species Reactivity: | Murine (Ms) Rat (Rt) |
| Immunogen: | Synthetic peptide corresponding to residues M(1) S A T A A T V P P A A P A G E G G(18) C of rat VAMP-2. |
| Ordering Information | ||||
| Pierce Anti-VAMP2 Polyclonal Antibody | ||||
| Product Number | Pkg. Size | Price | Purchase | |
| PA1-766 | 100 µg | $358.00 | ||
| Storage: | -20º C, Avoid Freeze/Thaw Cycles |
| Form: | 100 µg of epitope affinity purified IgG (1 mg/ml) in PBS containing 1 mg/ml BSA and 0.05% sodium azide. |
| Applications | Dilution |
| Immunoprecipitation (IP) | Assay dependent |
| Western Blot (WB) | 0.3 µg/ml |
| Product Specific Information |
| PA1-766 detects vesicle associated membrane protein 2 (VAMP-2) from rat and mouse tissues. PA1-766 has been successfully used in Western blot and immunoprecipitation procedures. By Western blot, this antibody detects a 19 kDa protein representing VAMP-2 from rat brain whole protein extract. The PA1-766 immunogen is a synthetic peptide corresponding to residues M(1) S A T A A T V P P A A P A G E G G(18) C of rat VAMP-2. This immunizing peptide (Cat. # PEP-101) is available for use in neutralization and control experiments. Figure 1 shows a Western blot of VAMP-2 on rat brain extract using PA1-766. |
| General Information |
| The vesicle associated membrane proteins (VAMP) or synaptobrevins are calcium binding proteins specific to eukaryotes. VAMPs, along with synaptosomal associated protein of 25 kDa (SNAP-25) and syntaxin, form the core complex of soluble NSF attachment protein receptor (SNARE) proteins that interact with the soluble proteins N-ethylmaleimide-sensitive factor (NSF) and alpha-SNAP. These membrane associated proteins play a key role in the regulation of vesicle membrane fusion with the plasma membrane. The Clostridium tetani neurotoxin is a metalloprotease with specificity for VAMP. In Alzheimer’s disease, VAMP levels of all isoforms appear to be significantly lowered. It is suggested that VAMP-2 is a resident protein of the insulin-sensitive glucose transporter type 4 (GLUT4) compartment and that it is required for GLUT4 vesicle incorporation into the cell surface in response to insulin. |
(This product is for In Vitro experimental use only.)
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