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DOPAMINE BETA HYDROXYLASE ANTIBODIES > DOPAMINE BETA HYDROXYLASE POLYCLONAL ANTIBODY PA1-4655
Anti-Dopamine beta Hydroxylase Polyclonal Antibody
Printable Datasheet
Synonyms:
DBH, Dopamine beta monooxygenase
Entrez Gene ID:
(Human) 1621
UniProt ID:
P09172
| Details | |
| Host / Isotype: | Rabbit |
| Class: | Polyclonal |
| Type: | Antibody |
| Species Reactivity: | Human (Hu) Non-human primate (Nhp) |
| Immunogen: | Peptide from the N-terminus region of human Dopamine-Hydroxylase (DBH), conjugated to KLH. |
| Ordering Information | ||||
| Pierce Anti-Dopamine beta Hydroxylase Polyclonal Antibody | ||||
| Product Number | Pkg. Size | Price | Purchase | |
| PA1-4655 | 100 µl | $285.00 | ||
| Storage: | -20º C, Avoid Freeze/Thaw Cycles |
| Form: | 100 ul of affinity purified IgG in 10 mM HEPES (pH 7.5), 150 mM NaCl, 100 ug per ml BSA and 50% glycerol. |
| Applications | Dilution |
| Western Blot (WB) | 1:1000 |
| Product Specific Information |
| PA1-4655 detects Dopamine beta-Hydroxylase (N-terminus) in human and non-human primate samples. PA1-4655 has been successfully used in Western blotting. It is specific for the ~75 kDa DBH protein in Western blots of human adrenal medulla. It also recognizes DBH in monkey tissues. PA1-4655 immunogen is a peptide from the N-terminus region of human Dopamine '-Hydroxylase (DBH), conjugated to keyhole limpet hemocyanin (KLH). The sequence of the immunogen is identical in human and non-human primate. Figure 1 shows a Western blot of human adrenal medulla. As shown in the autoradiograph, the antibody is specific for the ~75 kDa DBH protein. |
| General Information |
| DBH catalyzes the conversion of dopamine to norepinephrine and serves as a marker of noradrenergic cells. DBH antibodies and antibodies for other markers of catecholamine biosynthesis are widely used as markers for dopaminergic and noradrenergic neurons in a variety of applications including depression, schizophrenia, Parkinson’s disease and drug abuse (Kish et al., 2001; Zhu et al., 2000; Zhu et al., 1999). The expression of DBH is also elevated during stress (Sabban and Kvetnansky, 2001). |
(This product is for In Vitro experimental use only.)
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