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Anti-Dopamine beta Hydroxylase Polyclonal Antibody

Printable Datasheet

Details
Host / Isotype: Rabbit
Class: Polyclonal
Type: Antibody
Clone:
Label:
Species Reactivity: Human (Hu) Non-human primate (Nhp)
Immunogen: Peptide from the N-terminus region of human Dopamine-Hydroxylase (DBH), conjugated to KLH.
Applications Dilution
Western Blot (WB) 1:1000
Ordering Information
Pierce Anti-Dopamine beta Hydroxylase Polyclonal Antibody
Product Number Pkg Size Price


PA1-4655 100 µl $285.00
Storage: -20º C, Avoid Freeze/Thaw Cycles
Form: 100 ul of affinity purified IgG in 10 mM HEPES (pH 7.5), 150 mM NaCl, 100 ug per ml BSA and 50% glycerol.


Product Specific Information General Information
PA1-4655 detects Dopamine beta-Hydroxylase (N-terminus) in human and non-human primate samples.

PA1-4655 has been successfully used in Western blotting. It is specific for the ~75 kDa DBH protein in Western blots of human adrenal medulla. It also recognizes DBH in monkey tissues.

PA1-4655 immunogen is a peptide from the N-terminus region of human Dopamine '-Hydroxylase (DBH), conjugated to keyhole limpet hemocyanin (KLH). The sequence of the immunogen is identical in human and non-human primate.

Figure 1 shows a Western blot of human adrenal medulla. As shown in the autoradiograph, the antibody is specific for the ~75 kDa DBH protein.
DBH catalyzes the conversion of dopamine to norepinephrine and serves as a marker of noradrenergic cells. DBH antibodies and antibodies for other markers of catecholamine biosynthesis are widely used as markers for dopaminergic and noradrenergic
neurons in a variety of applications including depression, schizophrenia, Parkinson’s disease and drug abuse (Kish et al., 2001; Zhu et al., 2000; Zhu et al., 1999). The expression of DBH is also elevated during stress (Sabban and Kvetnansky, 2001).
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