Anti-Noggin Polyclonal Antibody
| Host / Isotype: |
Rabbit / IgG |
| Class: |
Polyclonal |
| Type: |
Antibody |
| Clone: |
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| Label: |
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| Species Reactivity: |
Human (Hu) |
| Immunogen: |
Synthetic peptide corresponding to residues P(156) V L Y A W N D L G S R F W P(170) of the human Noggin (NOG) protein. |
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| Pierce Anti-Noggin Polyclonal Antibody |
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| Product Number |
Pkg Size |
Price |
|
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| PA1-4521 |
100 µg |
$322.00 |
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| Storage: |
-20º C, Avoid Freeze/Thaw Cycles |
| Form: |
100 ug affinity purified antibody in PBS containing 0.02% sodium azide. |
PA1-4521 detects Noggin (NOG) in human samples. The immunizing peptide sequence is 100% conserved in rat and mouse.
PA1-4521 has been successfully used in Western blot procedures. This antibody is specific for the ~32 kDa protein representing Noggin (NOG) .
PA1-4521 immunogen is a synthetic peptide corresponding to residues 156-170 of the human Noggin (NOG) protein.
Figure 1 shows a Western blot of human hippocampus tissue lysate showing specific labeling of the ~32 kDa Noggin (NOG) protein. |
Noggin is involved in numerous developmental processes, such as neural tube fusion and joint formation. The morphogenesis of organs is initiated by a downgrowth from a layer of epithelial stem cells. This process is achieved through the receipt of signals from 1) a WNT protein (WNT3A) to stabilize beta-catenin; and 2) Noggin, which is a bone morphogenetic protein inhibitor. Noggin mutations in unrelated families with proximal symphalangism (SYM1) and multiple synostoses syndrome (SYNS1) have been identified, which have multiple joint fusion as their principal defect. |
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No references for this product. |
This product is for In Vitro experimental use only
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