Anti-Noggin Polyclonal Antibody
Printable Datasheet
Synonyms:
Noggin, Mouse Homolog of; Noggin precursor, NOG
Entrez Gene ID:
(Human) 9241
UniProt ID:
Q13253
| Details | |
| Host / Isotype: | Rabbit / IgG |
| Class: | Polyclonal |
| Type: | Antibody |
| Species Reactivity: | Human (Hu) |
| Immunogen: | Synthetic peptide corresponding to residues P(156) V L Y A W N D L G S R F W P(170) of the human Noggin (NOG) protein. |
| Ordering Information | ||||
| Pierce Anti-Noggin Polyclonal Antibody | ||||
| Product Number | Pkg. Size | Price | Purchase | |
| PA1-4521 | 100 µg | $322.00 | ||
| Storage: | -20º C, Avoid Freeze/Thaw Cycles |
| Form: | 100 ug affinity purified antibody in PBS containing 0.02% sodium azide. |
| Applications | Dilution |
| Western Blot (WB) | 1:1000 |
| Product Specific Information |
| PA1-4521 detects Noggin (NOG) in human samples. The immunizing peptide sequence is 100% conserved in rat and mouse. PA1-4521 has been successfully used in Western blot procedures. This antibody is specific for the ~32 kDa protein representing Noggin (NOG) . PA1-4521 immunogen is a synthetic peptide corresponding to residues 156-170 of the human Noggin (NOG) protein. Figure 1 shows a Western blot of human hippocampus tissue lysate showing specific labeling of the ~32 kDa Noggin (NOG) protein. |
| General Information |
| Noggin is involved in numerous developmental processes, such as neural tube fusion and joint formation. The morphogenesis of organs is initiated by a downgrowth from a layer of epithelial stem cells. This process is achieved through the receipt of signals from 1) a WNT protein (WNT3A) to stabilize beta-catenin; and 2) Noggin, which is a bone morphogenetic protein inhibitor. Noggin mutations in unrelated families with proximal symphalangism (SYM1) and multiple synostoses syndrome (SYNS1) have been identified, which have multiple joint fusion as their principal defect. |
(This product is for In Vitro experimental use only.)
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