Anti-APE1 Polyclonal Antibody
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Synonyms:
APE
Entrez Gene ID:
(Human) 328
UniProt ID:
P27695
| Details | |
| Host / Isotype: | Rabbit / IgG |
| Class: | Polyclonal |
| Type: | Antibody |
| Species Reactivity: | Human (Hu) |
| Immunogen: | Synthetic peptides corresponding to residues 36-52 and 216-232 of human APE. |
| Ordering Information | ||||
| Pierce Anti-APE1 Polyclonal Antibody | ||||
| Product Number | Pkg. Size | Price | Purchase | |
| PA1-41227 | 100 µg | $285.00 | ||
| Storage: | -20°C |
| Form: | 100 µg antibody in 200 µl PBS containing 0.02% sodium azide. |
| Applications | Dilution |
| Western Blot (WB) | 1-2 µg/ml |
| Product Specific Information |
| PA1-41227 detects APE in human samples. PA1-41227 has been successfully used in Western blot applications. The PA1-41227 immunogen is a mix of synthetic peptides corresponding to residues 36-52 and 216-232 of human APE. |
| General Information |
| Human apurinic (apyrimidinic) endonuclease/redox-factor 1 (APE/Ref-1) is involved in the repair of DNA damage as well as in the transcriptional regulation of genes. The repair function of the protein is located on its C-terminal region. Activation of transcription factors, which occurs via a redox-based mechanism, pertains to a approximately 6 kDa N-terminal fragment with Cys-65 being of essential importance. Ape1/ref-1 has been shown to stimulate the DNA binding activity of numerous transcription factors that are involved in cancer promotion and progression such as Fos, Jun, NF (B, PAX, HIF-1(, HLF and p53. APE/Ref-1 is part of the cellular response to oxidative stress and protects cells from the genotoxic and cytotoxic effect of oxidizing agents. Thus, specific downmodulation of APE/Ref-1 activity in tumors might be considered as a novel therapeutic approach in tumor therapy. |
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Western Blot with anti-APE1 Polyclonal Antibody (PA1-41227)
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(This product is for In Vitro experimental use only.)
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PO
Box 117, Rockford, IL 61105 USA |
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