Anti-Activin Receptor IA Polyclonal Antibody
| Host / Isotype: |
Rabbit / IgG |
| Class: |
Polyclonal |
| Type: |
Antibody |
| Clone: |
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| Label: |
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| Species Reactivity: |
Human (Hu) Murine (Ms) Rat (Rt) |
| Immunogen: |
Synthetic peptide corresponding to residues 475-525 of human ACVR1. |
|
| Western Blot (WB) |
3-5 µg/ml |
| Pierce Anti-Activin Receptor IA Polyclonal Antibody |
|
| Product Number |
Pkg Size |
Price |
|
|
| PA1-41185 |
100 µg |
$342.00 |
|
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| Storage: |
-20º C, Avoid Freeze/Thaw Cycles |
| Form: |
100 µg of Protein G purified antibody in 200 µl PBS containing 0.2% gelatin and 0.05% sodium azide. |
PA1-41185 detects Activin Receptor Type 1A in human, rat and murine samples.
PA1-41185 has been successfully used in Western blot applications. By Western blot, this antibody detects a ~54 kDa band representing Activin Receptor Type IA. Additional non-specific bands at ~14 and 27 kDa may also be detected in human kidney samples.
The PA1-41185 immunogen is a synthetic peptide corresponding to residues 475-525 of human ACVR1. |
Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I ( I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling; and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. |
No references for this product. |
This product is for In Vitro experimental use only
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