Anti-Phospho-JAK2 (Tyr1007/1008) Polyclonal Antibody
| Host / Isotype: |
Rabbit / IgG |
| Class: |
Polyclonal |
| Type: |
Antibody |
| Clone: |
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| Label: |
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| Species Reactivity: |
Human (Hu) Murine (Ms) Rat (Rt) |
| Immunogen: |
Synthetic phosphopeptide corresponding to residues Q(1003) D K E Y(p) Y(p) K V K(1011) of human, mouse, and rat JAK2. |
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| Western Blot (WB) |
Assay Dependent |
| Pierce Anti-Phospho-JAK2 (Tyr1007/1008) Polyclonal Antibody |
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| Product Number |
Pkg Size |
Price |
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| PA1-37958 |
50 µg |
$408.00 |
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| Storage: |
4º C |
| Form: |
50 µg of epitope affinity purified IgG (0.2 mg/ml) in 10 mM PBS, pH 7.4 containing sodium azide and BSA. |
PA1-37958 detects Phospho-JAK2 (Tyr1007/1008) from human, mouse, and rat samples.
PA1-37958 has been successfully used in Western blot applications.
The PA1-37958 immunogen is a synthetic phosphopeptide corresponding to residues Q(1003) D K E Y(p) Y(p) K V K(1011) of human, mouse, and rat JAK2.
Figure 1 illustrates Western blot detection of Phospho-Jak2 in whole tissue lysate from GH-treated mouse muscle probed with PA1-37958 (Lanes 1 & 2) or with pre-absorbed antibody with immunizing peptide (lane3). |
Janus Activating Kinase 2 (JAK2) is one of a number of related tyrosine kinases involved in cytoplasmic signal transduction. In response to a varitety of cytokine or related factors (e.g., interferon, interleukins), JAKs are activated via phosphorylation at 2 adjacent tyrosine residues. The activation of JAKs can lead to the phosphorylation of STAT (signal transducers and activatiors of transcription) proteins, which dimerize and translocate to the nucleus. Once translocated to the nucleus, the STAT proteins can modify transcription of numerous genes, including interferon-stimulated genes. JAK2 is required for the IFN gamma-receptor complex initiation and JAK1 functions as an amplifier. However, active JAK1 may be required for complex responses. Some studies have suggested that the role of JAK2 might be performed by Tyk2 and JAK3, if they were positioned correctly within the IFN gamma-receptor complex. |
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No references for this product. |
This product is for In Vitro experimental use only
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