| Details | |
| Host / Isotype: | Rabbit |
| Class: | Polyclonal |
| Type: | Antibody |
| Species Reactivity: | Human (Hu) Non-human primate (Nhp) |
| Immunogen: | Human AANAT |
| Ordering Information | ||||
| Pierce Anti-AANAT Polyclonal Antibody | ||||
| Product Number | Pkg. Size | Price | Purchase | |
| PA1-32265 | 100 µl | $421.00 | ||
| Storage: | -20º C, Avoid Freeze/Thaw Cycles |
| Form: | 100 µl of antibody in 0.1N glacial acetic acid containing 0.1% BSA and neutralized using 10X PBS containing NaOH to a final pH of 6.8.. For extended storage add 50% glycerol, aliquot and store at -20ºC or below. |
| Applications | Dilution |
| Western Blot (WB) | Assay dependent |
| Product Specific Information |
| PA1-32265 detects AANAT from human, non-human primate samples. PA1-32265 has been successfully used in Western blot applications. The PA1-32265 immunogen is: Human AANAT |
| General Information |
| The protein encoded by this gene belongs to the acetyltransferase superfamily. It is the penultimate enzyme in melatonin synthesis and controls the night/day rhythm in melatonin production in the vertebrate pineal gland. Melatonin is essential for the function of the circadian clock that influences activity and sleep. This enzyme is regulated by cAMP-dependent phosphorylation that promotes its interaction with 14-3-3 proteins and thus protects the enzyme against proteasomal degradation. This gene may contribute to numerous genetic diseases such as delayed sleep phase syndrome. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. |
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