Anti-WAS Polyclonal Antibody
Printable Datasheet
Synonyms:
IMD2, THC, THC1, WASP
Entrez Gene ID:
(Human) 7454
UniProt ID:
P42768
| Details | |
| Host / Isotype: | Chicken / IgY |
| Class: | Polyclonal |
| Type: | Antibody |
| Species Reactivity: | Human (Hu) |
| Immunogen: | Synthetic peptide, corresponding to amino acids 313 to 425 of Human WASP . |
| Ordering Information | ||||
| Pierce Anti-WAS Polyclonal Antibody | ||||
| Product Number | Pkg. Size | Price | Purchase | |
| PA1-28294 | 50 µg | $463.00 | ||
| Storage: | -20º C, Avoid Freeze/Thaw Cycles |
| Form: | 50 µg of immunogen affinity purified antibody in PBS. |
| Applications | Dilution |
| Western Blot (WB) | Assay dependent |
| Product Specific Information |
| PA1-28294 detects WAS from human samples. PA1-28294 has been successfully used in Western blot applications. The PA1-28294 immunogen is: Synthetic peptide, corresponding to amino acids 313 to 425 of Human WASP . |
| General Information |
| The Wiskott-Aldrich syndrome (WAS) family of proteins share similar domain structure, and are involved in transduction of signals from receptors on the cell surface to the actin cytoskeleton. The presence of a number of different motifs suggests that they are regulated by a number of different stimuli, and interact with multiple proteins. Recent studies have demonstrated that these proteins, directly or indirectly, associate with the small GTPase, Cdc42, known to regulate formation of actin filaments, and the cytoskeletal organizing complex, Arp2/3. Wiskott-Aldrich syndrome is a rare, inherited, X-linked, recessive disease characterized by immune dysregulation and microthrombocytopenia, and is caused by mutations in the WAS gene. The WAS gene product is a cytoplasmic protein, expressed exclusively in hematopoietic cells, which show signalling and cytoskeletal abnormalities in WAS patients. A transcript variant arising as a result of alternative promoter usage, and containing a different 5' UTR sequence, has been described, however, its full-length nature is not known. |
(This product is for In Vitro experimental use only.)
 |
|||||||||||||
PO
Box 117, Rockford, IL 61105 USA |
 |
 |
