| Details | |
| Host / Isotype: | Rabbit / IgG |
| Class: | Polyclonal |
| Type: | Antibody |
| Species Reactivity: | Human (Hu) Murine (Ms) Rat (Rt) |
| Immunogen: | Synthetic peptide corresponding to residues C-N(411) E F Y D G D H D N D K E S D V E I(428) of human HDAC 3, conjugated to KLH. |
| Ordering Information | ||||
| Pierce Anti-HDAC3 DISCONTINUED Polyclonal Antibody | ||||
| Product Number | Pkg. Size | Price | Purchase | |
| PA1-26833 | 50 µl | $0.00 | ||
| Storage: | -20º C, Avoid Freeze/Thaw Cycles |
| Form: | 50 µl of IgG fraction antibody in 0.01M PBS with 15 mM sodium azide; pH 7.4. |
| Applications | Dilution |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:500 |
| Immunoprecipitation (IP) | 1:2,500 |
| Western Blot (WB) | 1:2,000 |
| Product Specific Information |
| PA1-26833 detects HDAC3 from human, mouse, and rat samples. PA1-26833 has been successfully used in immunohistochemistry (paraffin), immunoprecipitation, and Western blot procedures. The PA1-26833 immunogen is a synthetic peptide corresponding to residues C-N(411) E F Y D G D H D N D K E S D V E I(428) of human HDAC 3, conjugated to KLH. |
| General Information |
| Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to the histone deacetylase/acuc/apha family. It has histone deacetylase activity and represses transcription when tethered to a promoter. It may participate in the regulation of transcription through its binding with the zinc-finger transcription factor YY1. This protein can also down-regulate p53 function and thus modulate cell growth and apoptosis. This gene is regarded as a potential tumor suppressor gene. |
|
|||||||||||||
PO
Box 117, Rockford, IL 61105 USA |
|