| Details | |
| Host / Isotype: | Rabbit / IgG |
| Class: | Polyclonal |
| Type: | Antibody |
| Species Reactivity: | Human (Hu) |
| Ordering Information | ||||
| Pierce Anti-NAIP Polyclonal Antibody | ||||
| Product Number | Pkg. Size | Price | Purchase | |
| PA1-26478 | 50 µg | $354.00 | ||
| Storage: | -80º C, Avoid Freeze/Thaw Cycles |
| Form: | 50 µg of immunogen affinity purified antibody (0.2 mg/ml) in PBS, 50% glycerol, 1% BSA with 0.02% sodium azide; pH 7.2. |
| Applications | Dilution |
| Western Blot (WB) | 1.0 µg/ml |
| Product Specific Information |
| PA1-26478 detects NAIP from human samples. PA1-26478 has been successfully used in Western blot procedures. |
| General Information |
| This gene is part of a 500 kb inverted duplication on chromosome 5q13. This duplicated region contains at least four genes and repetitive elements which make it prone to rearrangements and deletions. The repetitiveness and complexity of the sequence have also caused difficulty in determining the organization of this genomic region. This copy of the gene is full length; additional copies with truncations and internal deletions are also present in this region of chromosome 5q13. It is thought that this gene is a modifier of spinal muscular atrophy caused by mutations in a neighboring gene, SMN1. The protein encoded by this gene contains regions of homology to two baculovirus inhibitor of apoptosis proteins, and it is able to suppress apoptosis induced by various signals. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. |
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