| Details | |
| Host / Isotype: | Rabbit / IgG |
| Class: | Polyclonal |
| Type: | Antibody |
| Species Reactivity: | Human (Hu) |
| Immunogen: | Synthetic peptide corresponding to a portion of human AMACR. |
| Ordering Information | ||||
| Pierce Anti-AMACR Polyclonal Antibody | ||||
| Product Number | Pkg. Size | Price | Purchase | |
| PA1-25522 | 500 µl | $354.00 | ||
| Storage: | -20º C, Avoid Freeze/Thaw Cycles |
| Form: | 500 µl of IgG fraction antibody with 0.05% sodium azide. |
| Applications | Dilution |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:25 |
| Product Specific Information |
| PA1-25522 detects AMACR from human samples. PA1-25522 has been successfully used in immunohistochemistry (paraffin) procedures. The PA1-25522 immunogen is a synthetic peptide corresponding to a portion of human AMACR. |
| General Information |
| This gene encodes a racemase. The encoded enzyme interconverts pristanoyl-CoA and C27-bile acylCoAs between their (R)- and (S)-stereoisomers. The conversion to the (S)-stereoisomers is necessary for degradation of these substrates by peroxisomal beta-oxidation. Encoded proteins from this locus localize to both mitochondria and peroxisomes. Mutations in this gene may be associated with adult-onset sensorimotor neuropathy, pigmentary retinopathy, and adrenomyeloneuropathy due to defects in bile acid synthesis. Alternatively spliced transcript variants have been described. |
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