Anti-UBE3A Polyclonal Antibody
Printable Datasheet
Synonyms:
ANCR, AS, E6-AP, EPVE6AP, FLJ26981, HPVE6A
Entrez Gene ID:
(Human) 7337
UniProt ID:
Q05086
| Details | |
| Host / Isotype: | Rabbit / IgG |
| Class: | Polyclonal |
| Type: | Antibody |
| Species Reactivity: | Human (Hu) |
| Immunogen: | Synthetic peptide corresponding to a portion of human ubiquitin protein ligase E3A encoded within exon 6 (LocusLink ID 7337). |
| Ordering Information | ||||
| Pierce Anti-UBE3A Polyclonal Antibody | ||||
| Product Number | Pkg. Size | Price | Purchase | |
| PA1-24716 | 50 µg | $354.00 | ||
| Storage: | -20º C, Avoid Freeze/Thaw Cycles |
| Form: | 50 µg of immunogen affinity purified antibody (1 mg/ml) in Tris-citrate/phosphate with 0.1% sodium azide; pH 7-8. |
| Applications | Dilution |
| Immunoprecipitation (IP) | 1 - 4 µg/mg |
| Product Specific Information |
| PA1-24716 detects UBE3A from human samples. PA1-24716 is expected to cross react with mouse due to sequence homology. PA1-24716 has been successfully used in immunoprecipitation procedures. The PA1-24716 immunogen is a synthetic peptide corresponding to a portion of human ubiquitin protein ligase E3A encoded within exon 6 (LocusLink ID 7337). |
| General Information |
| This gene encodes an E3 ubiquitin-protein ligase, part of the ubiquitin protein degradation system. This imprinted gene is maternally expressed in brain and biallelically expressed in other tissues. Maternally inherited deletion of this gene causes Angelman Syndrome, characterized by severe motor and intellectual retardation, ataxia, hypotonia, epilepsy, absence of speech, and characteristic facies. The protein also interacts with the E6 protein of human papillomavirus types 16 and 18, resulting in ubiquitination and proteolysis of tumor protein p53. Alternative splicing of this gene results in three transcript variants encoding three isoforms with different N-termini. Additional transcript variants have been described, but their full length nature has not been determined. |
(This product is for In Vitro experimental use only.)
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