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VIMENTIN ANTIBODIES > VIMENTIN POLYCLONAL ANTIBODY PA1-20239
Anti-Vimentin Polyclonal Antibody
Printable Datasheet
Synonyms:
RP11-124N14.1, FLJ36605
Entrez Gene ID:
(Mammalia) 7431
UniProt ID:
P08670
| Details | |
| Host / Isotype: | Goat / IgG |
| Class: | Polyclonal |
| Type: | Antibody |
| Species Reactivity: | Mammalia (Mi) |
| Immunogen: | Purified vimentin from cultured human foreskin fibroblasts. |
| Ordering Information | ||||
| Pierce Anti-Vimentin Polyclonal Antibody | ||||
| Product Number | Pkg. Size | Price | Purchase | |
| PA1-20239 | 200 µl | $393.00 | ||
| Storage: | -20º C, Avoid Freeze/Thaw Cycles |
| Form: | 200 µl of whole antiserum antibody in 0.1% sodium azide. |
| Applications | Dilution |
| Immunocytochemistry (ICC) | Assay dependent |
| Immunofluorescence (IF) | 1/20 |
| Western Blot (WB) | Assay dependent |
| Product Specific Information |
| PA1-20239 detects Vimentin in most mammalian samples. PA1-20239 has been successfully used in immunocytochemistry, immunofluorescence, and Western blot procedures. The PA1-20239 immunogen is purified vimentin from cultured human foreskin fibroblasts. |
| General Information |
| Vimentin is a developmentally regulated intermediate filament protein (IFP) found in cells of mesenchymal origin. It is believed to be involved with the intracellular transport of proteins between the nucleus and plasma membrane. Unlike other IFP proteins, vimentin is expressed, along with desmin, during the early stages of cellular development. During the development process, vimentin is exchanged for new, tissue-specific IFPs. Vimentin has been implicated to be involved in the rate of steroid synthesis via its role as a storage network for steroidogenic cholesterol containing lipid droplets. Vimentin phosphorylation by a protein kinase causes the breakdown of intermediate filaments and activation of an ATP and myosin light chain dependent contractile event. This results in cytoskeletal changes that facilitate the interaction of the lipid droplets within mitochondria, and subsequent transport of cholesterol to the organelles leading to an increase in steroid synthesis. |
(This product is for In Vitro experimental use only.)
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