Anti-Parkin Polyclonal Antibody
Printable Datasheet
Synonyms:
Ubiquitin E3 ligase PRKN, Parkinson juvenile disease protein 2, Parkinson disease protein 2, Prkn, Park2
Entrez Gene ID:
(Rat) 56816
UniProt ID:
Q9JK66
| Details | |
| Host / Isotype: | Rabbit |
| Class: | Polyclonal |
| Type: | Antibody |
| Species Reactivity: | Rat (Rt) Guinea Pig (GP) |
| Immunogen: | Synthetic peptide corresponding to residues R I L G E E Q Y N R Y Q Q Y G A E E C of human Parkin. |
| Ordering Information | ||||
| Pierce Anti-Parkin Polyclonal Antibody | ||||
| Product Number | Pkg. Size | Price | Purchase | |
| PA1-18265 | 100 µl | $285.00 | ||
| Storage: | -20º C, Avoid Freeze/Thaw Cycles |
| Form: | 100 µl of lyophilized whole serum. Reconstitute in 100 µl of sterile water. |
| Applications | Dilution |
| ELISA (ELISA) | 1:500 |
| Immunohistochemistry (IHC) | 1:500 |
| Western Blot (WB) | 1:500 |
| Product Specific Information |
| PA1-18265 detects Parkin from rat and Guinea Pig samples. PA1-18265 has been successfully used in immunohistochemistry, Western blot, and ELISA procedures. The PA1-18265 immunogen is a synthetic peptide corresponding to residues R I L G E E Q Y N R Y Q Q Y G A E E C of human Parkin, conjugated to diphtheria toxoid. |
| General Information |
| Parkinson's disease is a common neurodegenerative disease with complex clinical features. Mutations in the gene, Parkin (PARK2), appear to be responsible for the pathogenesis of autosomal recessive juvenile Parkinsonism. Parkin plays a role in the ubiquitin-mediated proteolytic pathway by removal and/or detoxification of abnormally folded or damaged protein. Loss of this ubiquitin ligase activity appears to be the mechanism underlying pathogenesis of Parkin. Parkin may protect neurons against alpha synuclein toxicity, proteasomal dysfunction, gpr37 accumulation, and kainate-induced excitotoxicity. It may play a role in controlling neurotransmitter trafficking at the presynaptic terminal and in calcium-dependent exocytosis. Parkin also regulates cyclin e during neuronal apoptosis and may represent a tumor suppressor gene. |
(This product is for In Vitro experimental use only.)
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