Anti-Parkin Polyclonal Antibody
| Host / Isotype: |
Rabbit |
| Class: |
Polyclonal |
| Type: |
Antibody |
| Clone: |
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| Label: |
|
| Species Reactivity: |
Rat (Rt) Guinea Pig (GP) |
| Immunogen: |
Synthetic peptide corresponding to residues R I L G E E Q Y N R Y Q Q Y G A E E C of human Parkin. |
|
| ELISA (ELISA) |
1:500 |
| Immunohistochemistry (IHC) |
1:500 |
| Western Blot (WB) |
1:500 |
| Pierce Anti-Parkin Polyclonal Antibody |
|
| Product Number |
Pkg Size |
Price |
|
|
| PA1-18265 |
100 µl |
$285.00 |
|
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|
|
| Storage: |
-20º C, Avoid Freeze/Thaw Cycles |
| Form: |
100 µl of lyophilized whole serum. Reconstitute in 100 µl of sterile water. |
PA1-18265 detects Parkin from rat and Guinea Pig samples.
PA1-18265 has been successfully used in immunohistochemistry, Western blot, and ELISA procedures.
The PA1-18265 immunogen is a synthetic peptide corresponding to residues R I L G E E Q Y N R Y Q Q Y G A E E C of human Parkin, conjugated to diphtheria toxoid. |
Parkinson's disease is a common neurodegenerative disease with complex clinical features. Mutations in the gene, Parkin (PARK2), appear to be responsible for the pathogenesis of autosomal recessive juvenile Parkinsonism. Parkin plays a role in the ubiquitin-mediated proteolytic pathway by removal and/or detoxification of abnormally folded or damaged protein. Loss of this ubiquitin ligase activity appears to be the mechanism underlying pathogenesis of Parkin. Parkin may protect neurons against alpha synuclein toxicity, proteasomal dysfunction, gpr37 accumulation, and kainate-induced excitotoxicity. It may play a role in controlling neurotransmitter trafficking at the presynaptic terminal and in calcium-dependent exocytosis. Parkin also regulates cyclin e during neuronal apoptosis and may represent a tumor suppressor gene. |
No references for this product. |
This product is for In Vitro experimental use only
Printable Datasheet
