Anti-TARDBP Polyclonal Antibody
Printable Datasheet
Synonyms:
anti-TARD binding protein antibody, anti-TAR DNA-binding protein 43 antibody, anti-TDP-43 antibody, anti-TDP43 antibody
Entrez Gene ID:
(Human) 23435
UniProt ID:
Q13148
| Details | |
| Host / Isotype: | Rabbit |
| Class: | Polyclonal |
| Type: | Antibody |
| Species Reactivity: | Human (Hu) Murine (Ms) Non-human primate (Nhp) Chicken (Ck) Xenopus laevis (Xl) Zebrafish (Zf) |
| Immunogen: | Synthetic peptide corresponding to C terminal region within residues 350-414 of the human TARDBP protein. |
| Ordering Information | ||||
| Pierce Anti-TARDBP Polyclonal Antibody | ||||
| Product Number | Pkg. Size | Price | Purchase | |
| PA1-16996 | 100 µl | $340.00 | ||
| Storage: | 4º C, DO NOT FREEZE! |
| Form: | 100 µl of affinity purified antisera (1 mg/ml) in Tris-glycine, 150mM NaCl containing 0.05% sodium azide. |
| Applications | Dilution |
| Western Blot (WB) | 0.5 to 2.0 ug/ml |
| Product Specific Information |
| PA1-16996 detects TARDBP protein in human, nonhuman primate, murine, chicken, zebrafish and Cenopus laevis samples. PA1-16996 has been successfully used in Western blot procedures. In Western blot, PA1-16996 is specific for the ~45 kDa TARDBP protein. PA1-16996 immunogen is a synthetic peptide corresponding to residues 350-414 of the human TARDBP protein. Figure 1 shows a Western blot of HeLa WCE showing specific labeling of the ~45 kDa TARDBP protein. |
| General Information |
| The HIV1 virus gives rise to acquired immunodeficiency syndrome (AIDS). HIV1 contains an RNA genome which produces chromosomally integrated DNA during cellular replication. Gene activation of HIV1 by the transactivator Tat requires an RNA regulatory element TAR which is located downstream of the transcription initiation site. TARDBP is a transcriptional repressor that binds to the chromosomally integrated TAR DNA, preventing HIV1 expression. Additionally, this protein regulates alternative splicing of the CTFR gene, a similar pseudogene on chromosoome 20. TARDBP has also been recently been shown to abnormally accumulate in the post-mortem brain tissue of individuals diagnosed with ALS (Amyotrophic Lateral Sclerosis) and FTD (Frontal Temporal Dementia). This long-awaited conncection between these two diseases provides an explanation for the observed clinical overlap. |
(This product is for In Vitro experimental use only.)
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