Anti-BMI-1 Polyclonal Antibody
Printable Datasheet
Synonyms:
Pcgf4 antibody, Polycomb complex protein BMI-1 antibody, Polycomb group RING finger protein 4 antibody
Entrez Gene ID:
(Human) 12151
UniProt ID:
P25916
| Details | |
| Host / Isotype: | Rabbit |
| Class: | Polyclonal |
| Type: | Antibody |
| Species Reactivity: | Human (Hu) Murine (Ms) |
| Immunogen: | Synthetic peptide corresponding to an internal region within residues 1-100 of human Bmi1 [Swiss-Prot# P35226] . |
| Ordering Information | ||||
| Pierce Anti-BMI-1 Polyclonal Antibody | ||||
| Product Number | Pkg. Size | Price | Purchase | |
| PA1-16973 | 100 µl | $342.00 | ||
| Storage: | -20º C, Avoid Freeze/Thaw Cycles |
| Form: | 100 µl of immunogen affinity purified rabbit antisera (1.09 mg/ml) in Tris-glycine, 150mM NaCl, with 0.05% sodium azide. |
| Applications | Dilution |
| Western Blot (WB) | 0.5-2.0 µg/ml |
| Product Specific Information |
| PA1-16973 detects Bmi1 from human and mouse samples. PA1-16973 has been successfully used in Western blot applications. By Western blot, this antibody detects a ~37 kDa band, representing Bmi1. The PA1-16973 immunogen is a synthetic peptide corresponding to an internal region within residues 1-100 of human Bmi1. Figure 1 illustrates Western blot detection of Bmi1 from skeletal muscle using PA1-16973. |
| General Information |
| The Bmi1 oncogene has been shown to induce telomerase activity and immortalize human mammary epithelial cells. Bmi1 extends the replicative life span of human fibroblasts by suppressing the p16-dependent senescence pathway. Bmi1 is also important in maintaining stem cells' ability to self renew. It has also been termed an oncogene with aberrant expression in various carcinomas. It has been shown to be a negative regulator of p19Arf, Ink4a (p14Arf) and tp53 known tumor repressors. Ablation of Bmi1 is required for short term survival of cancer cells. |
(This product is for In Vitro experimental use only.)
 |
|||||||||||||
PO
Box 117, Rockford, IL 61105 USA |
 |
 |
