Anti-Vascular Endothelial Growth Factor A Polyclonal Antibody
| Host / Isotype: |
Rabbit |
| Class: |
Polyclonal |
| Type: |
Antibody |
| Clone: |
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| Label: |
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| Species Reactivity: |
Human (Hu) |
| Immunogen: |
Synthetic peptide between amino acids 150-250 of the internal region of human VEGFA protein sequence. |
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| Western Blot (WB) |
1 ug/ml |
| Pierce Anti-Vascular Endothelial Growth Factor A Polyclonal Antibody |
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| Product Number |
Pkg Size |
Price |
|
|
| PA1-16948 |
100 µl |
$342.00 |
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| Storage: |
4º C, DO NOT FREEZE! |
| Form: |
100 µl of purified antisera (1.1 mg/ml) in Tris-citrate/phosphate buffer [pH 7-8] containing 0.1% sodium azide. |
PA1-16948 detects VEGFA protein in human samples.
PA1-16948 has been successfully used in Western blot procedures. PA1-16948 is specific for the ~42 kDa VEGFA protein. Another faint band is seen at ~21 kDa, representing the monodomer form of VEGFA.
PA1-16948 immunogen is a synthetic peptide between amino acids 150-250 of the human VEGFA protein.
Figure 1 shows a Western blot of chimera transfected lysate showing specific labeling of the ~42 kDa VEGFA protein and the ~21 kDa monodomer form of VEGFA. |
VEGFA is a member of the PDGF/VEGF growth factor family and is often found as a disulfide linked homodimer. This protein is a glycosylated mitogen that specifically acts on endothelial cells and has various effects, including mediating increased vascular permeability, inducing angiogenesis, vasculogenesis and endothelial cell growth, promoting cell migration, and inhibiting apoptosis. Elevated levels of this protein is linked to POEMS syndrome, also known as Crow-Fukase syndrome.
VEGF and its high-affinity binding receptors, the tyrosine kinases FLK1 and FLT1, are thought to be important for the development of embryonic vasculature. It has been shown that an alternately spliced form of FLT1 produces a soluble protein, termed sFLT1, which binds vascular endothelial growth factor with high affinity, playing an inhibitory role in angiogenesis. |
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No references for this product. |
This product is for In Vitro experimental use only
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