Anti-ABCA1 Polyclonal Antibody
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Synonyms:
ABC 1, ABC Transporter 1, ABC1, ATP-binding Cassette 1, ATP-binding Cassette Transporter 1, CERP, Cholesterol Efflux Regulatory Protein, ABC-1
Entrez Gene ID:
(Human) 19, (Murine) 11303, (Rat) 313210
UniProt ID:
O95477
| Details | |
| Host / Isotype: | Rabbit |
| Class: | Polyclonal |
| Type: | Antibody |
| Species Reactivity: | Human (Hu) Murine (Ms) Rat (Rt) Hamster (Hm) |
| Immunogen: | Partial peptide sequence corresponding to a sequence between residues 1100-1300 of human ABCA1. |
| Ordering Information | ||||
| Pierce Anti-ABCA1 Polyclonal Antibody | ||||
| Product Number | Pkg. Size | Price | Purchase | |
| PA1-16789 | 100 µl | $342.00 | ||
| Storage: | 4º C, DO NOT FREEZE! |
| Form: | 100 µl of affinity purified rabbit antisera (1 mg/ml) in Tris-citrate; pH 7-8 with 0.02% sodium azide |
| Applications | Dilution |
| Flow Cytometry (FACS) | Assay dependent |
| Immunocytochemistry (ICC) | Assay dependent |
| Immunofluorescence (IF) | Assay dependent |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:200 |
| Immunoprecipitation (IP) | Assay dependent |
| Western Blot (WB) | 1:500 |
| Product Specific Information |
| PA1-16789 detects ABCA1 in human, mouse, hamster and rat samples. PA1-16789 has successfully been used in Western bot, flow cytometry, immunoprecipitation, immunofluorescence, and immunohistochemistry (paraffin) applications. The ABCA1 molecular weight is ~220 kDa. Important Note: ABCA1 is known to aggregate. DO NOT BOIL SAMPLES. The PA1-16789 immunogen is between residues 1100-1300 of human ABCA1. Figure 1 illustrates luminal and membrane immunostaining of ABCA1 in prostate epithelium using PA1-16789. |
| General Information |
| Mutations in the ABCA1 gene (ATP-binding cassette transporter 1) have been reported in Tangier disease (TD). TD is an autosomal recessive disorder characterized by an absence of plasma HDL, cholesterol ester depositing in the reticulo-endothelial system and deviations in cellular lipid trafficking. ABCA1 mediates the apo-A1 associated export of cholesterol and phospholipids from the cell. It is expressed on the plasma membrane and the Golgi complex, and is regulated by cholesterol flux. Regulation of the cholesterol flux between HDL and macrophages is competitive between ABCA1 and SR-BI. |
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Immunohistochemistry with anti-ABCA1 Polyclonal Antibody (PA1-16789)
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(This product is for In Vitro experimental use only.)
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Box 117, Rockford, IL 61105 USA |
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