Anti-Ogg1 Polyclonal Antibody
| Host / Isotype: |
Rabbit |
| Class: |
Polyclonal |
| Type: |
Antibody |
| Clone: |
|
| Label: |
|
| Species Reactivity: |
Human (Hu) |
| Immunogen: |
A peptide derived from the human Ogg1 (within amino acids 1-100). |
|
| Immunohistochemistry (IHC) |
1:100 |
| Western Blot (WB) |
1:500 |
| Pierce Anti-Ogg1 Polyclonal Antibody |
|
| Product Number |
Pkg Size |
Price |
|
|
| PA1-16505 |
100 µl |
$342.00 |
|
|
|
|
| Storage: |
4º C |
| Form: |
100 µl of affinity purified rabbit antisera (1.1 mg/ml) in PBS and 0.1% sodium azide. |
PA1-16505 detects Ogg1 in Human samples.
PA1-16505 has successfully been used in Western Blot and Immunohistochemistry applications. The Ogg1 molecular weight is 39 kDa.
The PA1-16505 immunizing agent corresponds to amino acids 1-100 from the human Ogg1. |
8-hydroxyguanine, a form of oxidative DNA damage induced by free radicals, causes G:C to T:A transversion. In E. Coli, three DNA repair enzymes exist to prevent the mutagenic effects of 8-hydroxyguanine. One of these enzymes, MutM, was found to have a functional yeast (yOgg1) and human (hOgg1) homologue. hOgg1 proteins efficiently released the 8-hydroxyguanine opposite the pyrimidine from DNA and cleaved the AP site in a manner similar to bacterial and yeast enzymes. Genetic backgrounds in control of the repair of damaged DNA are involved in the susceptibility to cancer development. The hOgg1 gene has been mapped to region 3p26.2, a region showing loss of heterozygosity (LOH) in a variety of cancers. In particular, 3p25-p26 is a common LOH region in lung cancer. |
No references for this product. |
This product is for In Vitro experimental use only
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