Anti-Phospho-JAK2 (Tyr221) Polyclonal Antibody
| Host / Isotype: |
Rabbit / IgG |
| Class: |
Polyclonal |
| Type: |
Antibody |
| Clone: |
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| Label: |
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| Species Reactivity: |
Human (Hu) Murine (Ms) Rat (Rt) |
| Immunogen: |
Synthetic phosphopeptide corresponding to human JAK2. |
|
| Immunohistochemistry (IHC) |
1:50 |
| Pierce Anti-Phospho-JAK2 (Tyr221) Polyclonal Antibody |
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| Product Number |
Pkg Size |
Price |
|
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| PA1-14230 |
200 µg |
$485.00 |
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| Storage: |
-20° C, Avoid Freeze/Thaw Cycles |
| Form: |
200 µg of antibody (1 mg/ml) in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02% sodium azide and 50% glycerol. |
PA1-14230 detects JAK2 in human, mouse and rat samples.
PA1-14230 has been successfully used in immunohistochemistry procedures.
The PA1-14230 immunogen is a synthesized phosphopeptide derived from human JAK2 around the phosphorylation site of Tyrosine 221(Q-D-Y-P-H-I).
Figure 1 shows specific staining of paraffin-embedded human breast carcinoma tissue using PA1-14230. |
Janus Activating Kinase 2 (JAK2) is one of a number of related tyrosine kinases involved in cytoplasmic signal transduction. In response to a varitety of cytokine or related factors (e.g., interferon, interleukins), JAKs are activated via phosphorylation at 2 adjacent tyrosine residues. The activation of JAKs can lead to the phosphorylation of STAT (signal transducers and activatiors of transcription) proteins, which dimerize and translocate to the nucleus. Once translocated to the nucleus, the STAT proteins can modify transcription of numerous genes, including interferon-stimulated genes. |
No references for this product. |
This product is for In Vitro experimental use only
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