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Anti-Notum Polyclonal Antibody

Printable Datasheet

Details
Host / Isotype: Rabbit / IgG
Class: Polyclonal
Type: Antibody
Clone:
Label:
Species Reactivity: Human (Hu) Murine (Ms)
Immunogen: Recombinant full-length notum protein from mouse.
Applications Dilution
Immunohistochemistry (IHC) Assay Dependent
Western Blot (WB) 1:1,000
Ordering Information
Pierce Anti-Notum Polyclonal Antibody
Product Number Pkg Size Price


PA1-12858 100 µg $368.00
Storage: -20º C, Avoid Freeze/Thaw Cycles
Form: 100 µg in PBS with 0.08% sodium azide.


Product Specific Information General Information
PA1-12858 detects Notum in human and mouse samples.

PA1-12858 has been successfully used in western blot and immunohistochemistry procedures.

The PA1-12858 immunogen is recombinant full-length notum protein from mouse.
Genetic studies in Drosophila have revealed a novel secreted antagonist for Wingless (Wg) signaling, referred to as Notum/Wingful (Wf). Wf/Notum encodes a protein of 430 amino acid residues, which is related to plant pectin acetylesterases of the a/ß-hydrolase superfamily. The main target of Notum action appears to be cell surface proteoglycans Dally and/or Dally-like (Dlp). Notum governs the extracellular Wg morphogen distribution via Dally and Dlp. Also, like some vertebrate Wnt antagonists, notum expression is activated by Wg signaling, revealing the existence of a feedback control mechanism in which Wg modifies its own gradient distribution. In vertebrate, proteoglycans related to Dally and Dlp likely play important roles in Wnt signaling which encodes a glypican that is required for Wnt-11 signaling. A single ortholog of Notum exists in the mouse and the human genome, implying that a similar regulatory mechanism may exist in vertebrates.
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