Anti-Notum Polyclonal Antibody
| Host / Isotype: |
Rabbit / IgG |
| Class: |
Polyclonal |
| Type: |
Antibody |
| Clone: |
|
| Label: |
|
| Species Reactivity: |
Human (Hu) Murine (Ms) |
| Immunogen: |
Recombinant full-length notum protein from mouse. |
|
| Immunohistochemistry (IHC) |
Assay Dependent |
| Western Blot (WB) |
1:1,000 |
| Pierce Anti-Notum Polyclonal Antibody |
|
| Product Number |
Pkg Size |
Price |
|
|
| PA1-12858 |
100 µg |
$368.00 |
|
|
|
|
| Storage: |
-20º C, Avoid Freeze/Thaw Cycles |
| Form: |
100 µg in PBS with 0.08% sodium azide. |
PA1-12858 detects Notum in human and mouse samples.
PA1-12858 has been successfully used in western blot and immunohistochemistry procedures.
The PA1-12858 immunogen is recombinant full-length notum protein from mouse. |
Genetic studies in Drosophila have revealed a novel secreted antagonist for Wingless (Wg) signaling, referred to as Notum/Wingful (Wf). Wf/Notum encodes a protein of 430 amino acid residues, which is related to plant pectin acetylesterases of the a/ß-hydrolase superfamily. The main target of Notum action appears to be cell surface proteoglycans Dally and/or Dally-like (Dlp). Notum governs the extracellular Wg morphogen distribution via Dally and Dlp. Also, like some vertebrate Wnt antagonists, notum expression is activated by Wg signaling, revealing the existence of a feedback control mechanism in which Wg modifies its own gradient distribution. In vertebrate, proteoglycans related to Dally and Dlp likely play important roles in Wnt signaling which encodes a glypican that is required for Wnt-11 signaling. A single ortholog of Notum exists in the mouse and the human genome, implying that a similar regulatory mechanism may exist in vertebrates. |
No references for this product. |
No Related items for this product. |
This product is for In Vitro experimental use only
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