Anti-Notum Polyclonal Antibody
Printable Datasheet
Entrez Gene ID:
(Human) 147111, (Murine) 77583
UniProt ID:
Q6P988
| Details | |
| Host / Isotype: | Rabbit / IgG |
| Class: | Polyclonal |
| Type: | Antibody |
| Species Reactivity: | Human (Hu) Murine (Ms) |
| Immunogen: | Recombinant full-length notum protein from mouse. |
| Ordering Information | ||||
| Pierce Anti-Notum Polyclonal Antibody | ||||
| Product Number | Pkg. Size | Price | Purchase | |
| PA1-12858 | 100 µg | $368.00 | ||
| Storage: | -20º C, Avoid Freeze/Thaw Cycles |
| Form: | 100 µg antibody (1 mg/ml) in PBS with 0.08% sodium azide. |
| Applications | Dilution |
| Immunohistochemistry (IHC) | Assay Dependent |
| Western Blot (WB) | 1:1,000 |
| Product Specific Information |
| PA1-12858 detects Notum in human and mouse samples. PA1-12858 has been successfully used in western blot and immunohistochemistry procedures. A suggested positive control for this product is HepG2 cell lysate. The PA1-12858 immunogen is recombinant full-length notum protein from mouse. |
| General Information |
| Genetic studies in Drosophila have revealed a novel secreted antagonist for Wingless (Wg) signaling, referred to as Notum/Wingful (Wf). Wf/Notum encodes a protein of 430 amino acid residues, which is related to plant pectin acetylesterases of the a/ß-hydrolase superfamily. The main target of Notum action appears to be cell surface proteoglycans Dally and/or Dally-like (Dlp). Notum governs the extracellular Wg morphogen distribution via Dally and Dlp. Also, like some vertebrate Wnt antagonists, notum expression is activated by Wg signaling, revealing the existence of a feedback control mechanism in which Wg modifies its own gradient distribution. In vertebrate, proteoglycans related to Dally and Dlp likely play important roles in Wnt signaling which encodes a glypican that is required for Wnt-11 signaling. A single ortholog of Notum exists in the mouse and the human genome, implying that a similar regulatory mechanism may exist in vertebrates. |
(This product is for In Vitro experimental use only.)
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