Anti-ATG7 Polyclonal Antibody
Printable Datasheet
Synonyms:
ATG7, APG7-like, APG7L, hAGP7, GSA7, APG7L, DKFZp434N0735, ubiquitin-activating enzyme E1-like protein
Entrez Gene ID:
(Human) 10533, (Murine) 74244, (Rat) 312647
UniProt ID:
P35739
| Details | |
| Host / Isotype: | Sheep |
| Class: | Polyclonal |
| Type: | Antibody |
| Species Reactivity: | Human (Hu) Murine (Ms) Rat (Rt) |
| Immunogen: | Synthetic peptide from human, rat, mouse autophagy-related protein 7. |
| Ordering Information | ||||
| Pierce Anti-ATG7 Polyclonal Antibody | ||||
| Product Number | Pkg. Size | Price | Purchase | |
| OSA00008W | 100 µl | $285.00 | ||
This product is available in North America and Europe only.
| Storage: | -20º C, Avoid Freeze/Thaw Cycles |
| Form: | 100 µl lyophilized polyclonal antibody in whole serum. Reconstitute in 100 µl of sterile water. Centrifuge to remove any insoluble material. |
| Applications | Dilution |
| Immunohistochemistry (IHC) | 1:200 |
| Western Blot (WB) | 1:200 |
| Product Specific Information |
| OSA00008W detects ATG7 in Human, rat and murine samples. OSA00008W has been successfully used in Western blot and Immunohistochemistry applications. The OSA00008W immunogen is from a synthetic peptide corresponding to a portion of human, rat, mouse autophagy-related protein 7 (ATG7, APG7-like, APG7L, hAGP7) conjugated to an immunogenic carrier protein. |
| General Information |
| This gene was identified based on homology to Pichia pastoris GSA7 and Saccharomyces cerevisiae APG7. In the yeast, the protein appears to be required for fusion of peroxisomal and vaculuolar membranes. The protein shows homlogy to the ATP-binding and catalytic sites of the E1 ubiquitin activating enzymes. Functions as an E1 enzyme essential for multisubstrates such as GABARAPL1 and ATG12. Forms intermediate conjugates with GABARAPL1 (GABARAPL2, GABARAP or MAP1ALC3). Formation of the final GABARAPL1-PE conjugate is essential for autophagy. Interacts with ATG3 and ATG12. The complex, composed of ATG3 and ATG7, plays a role in the conjugation of ATG12 to ATG5. Widely expressed, especially in kidney, liver, lymph nodes and bone marrow. The C-terminal part of the protein is essential for the dimerization and interaction with ATG3 and ATG12. |
(This product is for In Vitro experimental use only.)
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Box 117, Rockford, IL 61105 USA |
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