Anti-CCRL1 Polyclonal Antibody
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Synonyms:
Chemokine Receptor-Like 1
Entrez Gene ID:
(Human) 51554
UniProt ID:
Q9NPB9
| Details | |
| Host / Isotype: | Rabbit |
| Class: | Polyclonal |
| Type: | Antibody |
| Species Reactivity: | Human (Hu) |
| Immunogen: | Synthetic peptide (KLH conjugated) to the 1st cytoplasmic loop. |
| Ordering Information | ||||
| Pierce Anti-CCRL1 Polyclonal Antibody | ||||
| Product Number | Pkg. Size | Price | Purchase | |
| OPA1-15104 | 25 µg | $453.00 | ||
| Storage: | -20º C, Avoid Freeze/Thaw Cycles |
| Form: | 25 µg Phosphate buffered saline, PH 7.7 containing 0.01% sodium azide. |
| Applications | Dilution |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:100 |
| Product Specific Information |
| OPA1-15104 detects CCRL1 from human samples. OPA1-15104 has been successfully used in immunohistochemistry procedures. By immunohistochemistry, OPA1-15104 detects CCRL1 in formalin fixed, paraffin embedded human tissues. The OPA1-15104 immunogen is a synthetic peptide (KLH conjugated) corresponding to the 1st cytoplasmic loop. Figure 1 shows a staining of CCRL1 in human cells using OPA1-15104. |
| General Information |
| CCRL1 expression has been reported in heart, small intestine, and lung. ESTs have been isolated from breast, heart, heart/melanocyte/uterus, kidney, nasal cavity, pancreas, testis, and tonsil libraries. G-protein Coupled Receptors (GPCRs) comprise one of the largest families of signaling molecules with more than a thousand members currently predicted to exist. All GPCRs share a structural motif consisting of seven membrane-spanning helices, and exist in both active and inactive forms. An array of activating ligands participate in the conformation of GPCRs which leads to signaling via G-proteins and downstream effectors. Ongoing studies have also shown the vast series of reactions which participate in the negative regulation of GPCRs. This "turn-off" activity has tremendous implications for the physiological action of the cell, and continues to drive pharmacological research for new drug candidates. Two blockbuster drugs which have been developed as GPCR-targeted pharmaceuticals are Zyprexa (Eli Lilly) and Claritin (Schering-Plough) which have multi-billion dollar shares of the mental health and allergy markets, respectively. |
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Immunohistochemistry with anti-CCRL1 Polyclonal Antibody (OPA1-15104)
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(This product is for In Vitro experimental use only.)
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Box 117, Rockford, IL 61105 USA |
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