Anti-JAK2 Polyclonal Antibody
Printable Datasheet
Synonyms:
Tyrosine-protein kinase JAK2, Janus kinase 2
Entrez Gene ID:
(Human) 3717, (Murine) 16452
UniProt ID:
O60674
| Details | |
| Host / Isotype: | Rabbit |
| Class: | Polyclonal |
| Type: | Antibody |
| Species Reactivity: | Human (Hu) Murine (Ms) |
| Immunogen: | A synthetic peptide derived from the C-terminus of human JAK2. |
| Ordering Information | ||||
| Pierce Anti-JAK2 Polyclonal Antibody | ||||
| Product Number | Pkg. Size | Price | Purchase | |
| OPA1-03052A | 100 µg | $356.00 | ||
| Storage: | -20º C, Avoid Freeze/Thaw Cycles |
| Form: | 100 ul of epitope affinity purified antibody in Dulbecco's phosphate buffered saline (without Mg2+ and Ca2+), pH 7.3, 50% glycerol, 1.0 mg/mL BSA and 0.05% sodium azide. |
| Applications | Dilution |
| Western Blot (WB) | 1:1000 |
| Product Specific Information |
| OPA1-03052A detects JAK2 in human and mouse samples. This antibody is expected to react with rat samples based on 100% sequence homology. OPA1-03052A has been successfully used in Western blotting. By Western blot, this antibody detects an ~130 kDa protein representing JAK2. This antibody is useful in measuring total JAK2 protein levels. The OPA1-03052A immunogen is a synthetic peptide derived from the C-terminus region of human JAK2. This sequence is conserved in rat and mouse. |
| General Information |
| Janus Activating Kinase 2 (JAK2) is a 130 kDa tyrosine kinase involved in cytoplasmic signal transduction. Ligand binding to a variety of cell surface receptors (e.g., cytokine, growth factor, GPCRs) leads to an association of those receptors with JAK proteins, which are then activated via phosphorylation on tyrosines 1007 and 1008 in the kinase activation loop. Activated JAK proteins phosphorylate and activate STAT (signal transducers and activators of transcription) proteins, which then dimerize and translocate to the nucleus. Once in the nucleus, STAT proteins bind to DNA and modify the transcription of various genes, which can lead to various responses such as cell proliferation, cell survival and differentiation. The JAK2 antibody is useful as a positive control and for measuring total JAK2 protein levels to compare signals obtained with the JAK2 PSSA. |
(This product is for In Vitro experimental use only.)
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