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DCR2 DISCONTINUED ANTIBODIES > DCR2 DISCONTINUED POLYCLONAL ANTIBODY OPA1-01013
Anti-DcR2 DISCONTINUED Polyclonal Antibody
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Synonyms:
Decoy Receptor 2, Tumor necrosis factor receptor superfamily member 10D, TNF-related apoptosis-inducing ligand receptor 4, TRAIL receptor 4, TRAIL-R4,
Entrez Gene ID:
(Human) 1235
UniProt ID:
P51684
| Details | |
| Host / Isotype: | Rabbit |
| Class: | Polyclonal |
| Type: | Antibody |
| Species Reactivity: | Human (Hu) Murine (Ms) Rat (Rt) |
| Immunogen: | Synthetic peptide corresponding to amino acid residues 249-263 of human DcR2. |
| Ordering Information | ||||
| Pierce Anti-DcR2 DISCONTINUED Polyclonal Antibody | ||||
| Product Number | Pkg. Size | Price | Purchase | |
| OPA1-01013 | 100 µg | $339.00 | ||
| Storage: | -20º C, Avoid Freeze/Thaw Cycles |
| Form: | 100 ug of purified IgG (1 mg/ml) in PBS containing 0.02% sodium azide. |
| Applications | Dilution |
| Western Blot (WB) | 1:1,000 |
| Product Specific Information |
| OPA1-01013 detects decoy receptor 2 (DcR2) from human, mouse, and rat samples. OPA1-01013 has been successfully used in Western blot procedures. By Western blot, this antibody detects a single ~36 kDa protein representing DcR2 from HeLa cell lysate. OPA1-01013 immunizing peptide corresponds to amino acid residues 249-263 from human DcR2. Figure 1 shows a Western blot of DcR2 on HeLa cell lysate using OPA1-01013. |
| General Information |
| Apoptosis is induced by certain cytokines including TNF and Fas ligand in the TNF family through their death domain containing receptors. TRAIL/Apo2L is a new member of the TNF family and induces apoptosis of a variety of tumor cell lines. DR4 and DR5 are the recently identified functional receptors for TRAIL, and DcR1/TRID is a decoy receptor. Another member of the TRAIL receptor family was more recently identified and designated DcR2, TRAIL-R4, or TRUNDD. DcR2 has an extracellular TRAIL-binding domain but lacks intracellular death domain and does not induce apoptosis. Like DR4 and DR5, DcR2 transcript is widely expressed in normal human tissues. Overexpression of DcR2 attenuated TRAIL-induced apoptosis. |
(This product is for In Vitro experimental use only.)
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