Anti-DcR2 Polyclonal Antibody
| Host / Isotype: |
Rabbit |
| Class: |
Polyclonal |
| Type: |
Antibody |
| Clone: |
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| Label: |
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| Species Reactivity: |
Human (Hu) |
| Immunogen: |
Synthetic peptide corresponding to amino acid residues 249-263 of human DcR2. |
|
| Western Blot (WB) |
1:1,000 |
| Pierce Anti-DcR2 Polyclonal Antibody |
|
| Product Number |
Pkg Size |
Price |
|
|
| OPA1-01013 |
100 µg |
$339.00 |
|
|
|
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| Storage: |
-20º C, Avoid Freeze/Thaw Cycles |
| Form: |
100 ug of purified IgG (1 mg/ml) in 100 µl of PBS containing 0.02% sodium azide. |
OPA1-01013 detects decoy receptor 2 (DcR2) from human cells.
OPA1-01013 has been successfully used in Western blot procedures. By Western blot, this antibody detects a single ~36 kDa protein representing DcR2 from HeLa cell lysate.
OPA1-01013 immunizing peptide corresponds to amino acid residues 249-263 from human DcR2.
Figure 1 shows a Western blot of DcR2 on HeLa cell lysate using OPA1-01013. |
Apoptosis, or programmed cell death, occurs during normal cellular differentiation and development of multicellular organisms. Apoptosis is induced by certain cytokines including TNF (tumor necrosis factor) and Fas ligand of the TNF family through their death domain containing receptors, TNFR1 (tumor necrosis factor receptor 1) and Fas. Cell death signals are transduced by death domain (DD)-containing adapter molecules and members of the ICE (interleukin-1-beta converting enzyme)/CED-3 (C. elegans death receptor-3) protease family. A novel DD-containing molecule was recently cloned from mouse, human and monkey and designated Daxx (death associated protein 6). Daxx binds specifically to the Fas death domain and enhances Fas induced apoptosis and activates the Jun N-terminal kinase (JNK) pathway. Daxx is widely expressed in fetal and adult human and mouse tissues indicating its important function in Fas signaling pathways. |
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This product is for In Vitro experimental use only
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