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DAXX DISCONTINUED ANTIBODIES > DAXX DISCONTINUED POLYCLONAL ANTIBODY OPA1-01012
Anti-DAXX DISCONTINUED Polyclonal Antibody
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Synonyms:
Death domain-associated protein 6, Fas death domain-associated protein, ETS1-associated protein 1, EAP1
Entrez Gene ID:
(Human) 1616
UniProt ID:
Q9UER7
| Details | |
| Host / Isotype: | Rabbit |
| Class: | Polyclonal |
| Type: | Antibody |
| Species Reactivity: | Human (Hu) |
| Immunogen: | Synthetic Peptide: T(722) S V A T Q C D P E E I I V L S D S D(740) |
| Ordering Information | ||||
| Pierce Anti-DAXX DISCONTINUED Polyclonal Antibody | ||||
| Product Number | Pkg. Size | Price | Purchase | |
| OPA1-01012 | 100 µg | $339.00 | ||
| Storage: | -20º C, Avoid Freeze/Thaw Cycles |
| Form: | 100 ug of purified IgG (0.5 mg/ml) in 200 µl of PBS containing 0.02% sodium azide. |
| Applications | Dilution |
| Western Blot (WB) | Assay dependent |
| Product Specific Information |
| OPA1-01012 detects death associated protein 6 (Daxx) from human cells. OPA1-01012 has been used successfully in Western blot procedures. By Western blot, this antibody detects an ~120 kDa protein representing Daxx from HeLa cell lysate. OPA1-01012 immunizing peptide corresponds to amino acid residues 722-740 from human Daxx. OPA1-01012 immunizing peptide (Cat. # OPEP-01012) is available for use in neutralization and control experiments. Figure 1 shows a Western blot of Daxx in HeLa cell lysate using OPA1-01012. |
| General Information |
| Apoptosis, or programmed cell death, occurs during normal cellular differentiation and development of multicellular organisms. Apoptosis is induced by certain cytokines including TNF (tumor necrosis factor) and Fas ligand of the TNF family through their death domain containing receptors, TNFR1 (tumor necrosis factor receptor 1) and Fas. Cell death signals are transduced by death domain (DD)-containing adapter molecules and members of the ICE (interleukin-1-beta converting enzyme)/CED-3 (C. elegans death receptor-3) protease family. A novel DD-containing molecule was recently cloned from mouse, human and monkey and designated Daxx (death associated protein 6). Daxx binds specifically to the Fas death domain and enhances Fas induced apoptosis and activates the Jun N-terminal kinase (JNK) pathway. Daxx is widely expressed in fetal and adult human and mouse tissues indicating its important function in Fas signaling pathways. |
(This product is for In Vitro experimental use only.)
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