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ACETYLCHOLINESTERASE ANTIBODIES > ACETYLCHOLINESTERASE MONOCLONAL ANTIBODY MA3-042
Anti-Acetylcholinesterase Monoclonal Antibody
Printable Datasheet
Synonyms:
AChE, EC 3.1.1.7
Entrez Gene ID:
(Human) 43
UniProt ID:
P22303
| Details | |
| Host / Isotype: | Mouse / IgG2b |
| Class: | Monoclonal |
| Type: | Antibody |
| Clone: | HR2 |
| Species Reactivity: | Human (Hu) Rabbit (Rb) Bovine (Bv) Feline (Fe) Guinea Pig (GP) |
| Immunogen: | Purified human cerebellar acetylcholinesterase. |
| Ordering Information | ||||
| Pierce Anti-Acetylcholinesterase Monoclonal Antibody | ||||
| Product Number | Pkg. Size | Price | Purchase | |
| MA3-042 | 200 µl | $350.00 | ||
| Storage: | -20º C, Avoid Freeze/Thaw Cycles |
| Form: | 200 µl of PBS-diluted ascites containing 0.05% sodium azide. |
| Applications | Dilution |
| ELISA (ELISA) | Assay dependent |
| Immunohistochemistry (Frozen) (IHC (F)) | 1:50 |
| Immunoprecipitation (IP) | Assay dependent |
| Product Specific Information |
| MA3-042 detects acetylcholinesterase (AChE) from human, rabbit, guinea pig, bovine and cat tissues. This antibody does not cross react with rat, frog, or mouse AChE, and does not detect butyrylcholinesterase (BChE). MA3-042 has been successfully used in immunohistochemistry, immunoprecipitation and ELISA procedures. This antibody cannot be used in Western blot to detect AChE. Immunohistochemical staining of AChE in human brain samples with MA3-042 results in staining of nerve fibers and terminals. The MA3-042 antigen is purified human cerebellar acetylcholinesterase. |
| General Information |
| Cholinergic neurotransmission occurs in motor, autonomic and central nervous synapses and requires very rapid inactivation of its transmitter, acetylcholine (ACh). Acetylcholinesterase (AChE) rapidly hydrolyzes ACh to acetate and choline, thereby inactivating it. AChE is found in the neuromuscular junction anchored to the basal lamina which runs between the nerve terminal and muscle membrane. AChE is also found outside the nervous and neuromuscular system in blood, lymph, germ and liver cells suggesting a role for AChE not related to cholinergic transmission. Another less specific cholinesterase, butyrylcholinesterase (BChE), seems to contribute to the regulation of the ACh concentration in the synaptic cleft. |
| References: |
| Brain Research, 539: 233-238, 1991. |
| J. Neural. Transm., 34: 139-1450, 1991. |
| Cellular and Molecular Neurobiology, 8(1): 85-93, 1988. |
(This product is for In Vitro experimental use only.)
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