Anti-IDE Monoclonal Antibody
Printable Datasheet| Details | |
| Host / Isotype: | Mouse / IgG1 |
| Class: | Monoclonal |
| Type: | Antibody |
| Clone: | 9B12.225 |
| Species Reactivity: | Human (Hu) Rat (Rt) Non-human primate (Nhp) Hamster (Hm) |
| Immunogen: | purified human erythrocyte IDE. |
| Ordering Information | ||||
| Pierce Anti-IDE Monoclonal Antibody | ||||
| Product Number | Pkg. Size | Price | Purchase | |
| MA1-91428 | 100 µl | $350.87 | ||
| Storage: | -20º C, Avoid Freeze/Thaw Cycles |
| Form: | 100 µl of ascities (~1 mg/ml) |
| Applications | Dilution |
| Immunohistochemistry (Paraffin) (IHC (P)) | Assay dependent |
| Immunoprecipitation (IP) | 1:150 |
| Western Blot (WB) | 1:1000 |
| Product Specific Information |
| MA1-91428 detects IDE from human samples. Does not react with Murine MA1-91428 has been successfully used in immunohistochemistry (paraffin tissue), immunoprecipitation, Western blot applications. Detects a band ~110kDa. The MA1-91428 immunogen is purified human erythrocyte IDE. |
| General Information |
| Insulin-degrading enzyme (IDE) is a metalloprotease with a molecular weight of 110 kDa that is expressed in many tissue types, with high concentrations noted in brain. IDE has a preferential affinity for insulin such that the presence of insulin will inhibit IDE-mediated degradation of other substrates. IDE degrades a variety of other peptides including atrial natriuretic peptide and amylin. IDE catabolizes A-beta and has been implicated as a candidate enzyme responsible for the degradation and clearance of A-beta in the brain. IDE has also been shown to degrade the APP intracellular domain (AICD), a product of gamma-secretase cleaved APP that may function in nuclear signaling. |
(This product is for In Vitro experimental use only.)
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Box 117, Rockford, IL 61105 USA |
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