Anti-CRALBP Monoclonal Antibody
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Synonyms:
Cellular Retinaldehyde-Binding Protein
Entrez Gene ID:
(Human) 6017
UniProt ID:
P12271
| Details | |
| Host / Isotype: | Mouse / IgG1 |
| Class: | Monoclonal |
| Type: | Antibody |
| Clone: | B2 |
| Species Reactivity: | Human (Hu) Murine (Ms) Rat (Rt) Non-human primate (Nhp) Bovine (Bv) |
| Immunogen: | Human recombinant CRALBP. |
| Ordering Information | ||||
| Pierce Anti-CRALBP Monoclonal Antibody | ||||
| Product Number | Pkg. Size | Price | Purchase | |
| MA1-813 | 100 µg | $354.00 | ||
| Storage: | -20º C, Avoid Freeze/Thaw Cycles |
| Form: | 100 ug of protein A purified IgG (1mg/ml) in PBS containing 1 mg/ml BSA and 0.05% sodium azide. |
| Applications | Dilution |
| Immunofluorescence (IF) | 1 ug/ml |
| Immunohistochemistry (Frozen) (IHC (F)) | 1 ug/ml |
| Immunoprecipitation (IP) | Assay dependent |
| Western Blot (WB) | 0.02 ug/ml |
| Product Specific Information |
| MA1-813 detects CRALBP protein in bovine, human, mouse, non-human primate and rat samples. MA1-813 has successfully been used in Western blot, immunohistochemistry, immunoprecipitation, and immunofluorescence procedures. By Western blot, this antibody detects a 37 kDa protein representing human recombinant CRALBP. The MA1-813 immunogen is purified human recombinant CRALBP. Figure 1 illustrates immunohistostaining of CRALBP in frozen mouse retina sections using MA1-813. Figure 2 shows a Western blot of human recombinant CRALBP using MA1-813. |
| General Information |
| Cellular retinaldehyde-binding protein (CRALBP) plays an important role in the regeneration of 11-cis-retinal for use in rod visual pigments such as opsin and rhodopsin. Once 11-cis-retinal is photoisomerized in the rod outer segment, it is converted to all-trans-retinal and further modified into all-trans-retinol. All-trans-retinol then diffuses into the retinal pigment epithelium (RPE) to be converted back to 11-cis-retinol and further oxidized into 11-cis-retinal (both by CRALBP). Genetic mutations involving CRALBP’s lack of function have been linked to visual disease such as bothnia dystrophy, retinitis punctata albescens, retina pigmentosa, and Newfoundland rod-cone dystrophy. The presence of CRALBP serves as a marker for RPE and Muller glial cells of the retina. |
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Immunofluorescence with anti-CRALBP Monoclonal Antibody [B2] (MA1-813)
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(This product is for In Vitro experimental use only.)
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PO
Box 117, Rockford, IL 61105 USA |
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