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Anti-AKT3 Monoclonal Antibody

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Synonyms:
DKFZp434N0250, PKB-GAMMA, PKBG, PRKBG, RAC-PK-gamma, RAC-gamma, STK-2
Entrez Gene ID:
(Human) 10000, (Murine) 23797, (Rat) 29414
UniProt ID:
Q9Y243
Details
Host / Isotype: Mouse / IgG1
Class: Monoclonal
Type: Antibody
Clone: 66C1247.1
Species Reactivity: Human (Hu) Murine (Ms) Rat (Rt)
Immunogen: Human Akt3.
Ordering Information
Pierce Anti-AKT3 Monoclonal Antibody
Product Number Pkg. Size Price Purchase
MA1-41201 100 µg $285.00


Storage: -20°C
Form: 100 µg antibody in 200 µl PBS containing 0.02% sodium azide, 100 µg/ml BSA.


Applications Dilution
Western Blot (WB) 1-2 µg/ml
Product Specific Information
MA1-41201 detects AKT3 in human, rat and murine samples.

MA1-41201 has been successfully used in Western blot applications.

MA1-41201 is derived from a synthetic peptide corresponding to amino acid residues 119-136 (CSPTSQIDNIGEEEMDaS) of human akt3, GenBank no.  AF135794_1. This sequence is identical in human, mouse, rat, cow, dog, and chicken.
General Information
Akt, protein kinase B (PKB), is a serine/threonine kinase which is involved in many cellular signaling pathways and acts as a transducer of many functions initiated by growth factor receptors that activat phosphtidylinositol 3-kinase (PI 3-kinase). The major activity of Akt/PKB is to mediate cell survival. Akt/PKB is also believed to be a critical factor in the genesis of cancer as the tumor suppressor PTEN was found to antagonise PI-3 kinase and Akt/PKB kinase activity. There are 3 known isoforms of this enzyme in mammalian cells (1/alpha, 2/beta and 3/gamma). Akt1, 2 and 3 contain a key regulatory serine phosphorylation site in the carboxy-terminal region of the protein. Akt/PKB phosphorylation is critical for it activity.
Western Blot with anti-AKT3 Monoclonal Antibody [66C1247.1] (MA1-41201)
(This product is for In Vitro experimental use only.)


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