Anti-AKT3 Monoclonal Antibody
| Host / Isotype: |
Mouse / IgG1 |
| Class: |
Monoclonal |
| Type: |
Antibody |
| Clone: |
66C1247.1 |
| Label: |
|
| Species Reactivity: |
Human (Hu) Murine (Ms) Rat (Rt) |
| Immunogen: |
Human Akt3. |
|
| Western Blot (WB) |
1-2 µg/ml |
| Pierce Anti-AKT3 Monoclonal Antibody |
|
| Product Number |
Pkg Size |
Price |
|
|
| MA1-41201 |
100 µg |
$285.00 |
|
|
|
|
| Storage: |
-20°C |
| Form: |
100 µg antibody in 200 µl PBS containing 0.02% sodium azide, 100 µg/ml BSA. |
MA1-41201 detects AKT3 in human, rat and murine samples.
MA1-41201 has been successfully used in Western blot applications.
MA1-41201 is derived from a synthetic peptide corresponding to amino acid residues 119-136 (CSPTSQIDNIGEEEMDaS) of human akt3, GenBank no. AF135794_1. This sequence is identical in human, mouse, rat, cow, dog, and chicken. |
Akt, protein kinase B (PKB), is a serine/threonine kinase which is involved in many cellular signaling pathways and acts as a transducer of many functions initiated by growth factor receptors that activat phosphtidylinositol 3-kinase (PI 3-kinase). The major activity of Akt/PKB is to mediate cell survival. Akt/PKB is also believed to be a critical factor in the genesis of cancer as the tumor suppressor PTEN was found to antagonise PI-3 kinase and Akt/PKB kinase activity. There are 3 known isoforms of this enzyme in mammalian cells (1/alpha, 2/beta and 3/gamma). Akt1, 2 and 3 contain a key regulatory serine phosphorylation site in the carboxy-terminal region of the protein. Akt/PKB phosphorylation is critical for it activity. |
No references for this product. |
This product is for In Vitro experimental use only
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