| Details | |
| Host / Isotype: | Mouse |
| Class: | Monoclonal |
| Type: | Antibody |
| Clone: | SPM414 |
| Species Reactivity: | Human (Hu) |
| Immunogen: | Human recombinant L-plastin protein. |
| Ordering Information | ||||
| Pierce Anti-L-Plastin Monoclonal Antibody | ||||
| Product Number | Pkg. Size | Price | Purchase | |
| MA1-38061 | 200 µg | $468.00 | ||
| Storage: | 4º C |
| Form: | 200 µg of affinity purified IgG (0.2 mg/ml) in PBS containing sodium azide and BSA. |
| Applications | Dilution |
| Immunofluorescence (IF) | Assay Dependent |
| Immunoprecipitation (IP) | Assay Dependent |
| Western Blot (WB) | Assay Dependent |
| Product Specific Information |
| MA1-38061 detects L-Plastin from human samples. MA1-38061 has been successfully used in Western blot, immunoprecipitation, and immunofluorescence applications. The MA1-38061 immunogen is human recombinant L-plastin protein. |
| General Information |
| Plastins are a family of actin-binding proteins that are conserved throughout eukaryote evolution and expressed in most tissues of higher eukaryotes. In humans, two ubiquitous plastin isoforms (L and T) have been identified. Plastin 1 (otherwise known as Fimbrin) is a third distinct plastin isoform which is specifically expressed at high levels in the small intestine. The L isoform is expressed only in hemopoietic cell lineages, while the T isoform has been found in all other normal cells of solid tissues that have replicative potential (fibroblasts, endothelial cells, epithelial cells, melanocytes, etc.). However, L-plastin has been found in many types of malignant human cells of non-hemopoietic origin suggesting that its expression is induced accompanying tumorigenesis in solid tissues. |
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