Anti-ABCC5 Monoclonal Antibody
Printable Datasheet
Synonyms:
MRP5
Entrez Gene ID:
(Human) 10057
UniProt ID:
O15440
| Details | |
| Host / Isotype: | Rat / IgG2a |
| Class: | Monoclonal |
| Type: | Antibody |
| Clone: | M5II-54 |
| Species Reactivity: | Human (Hu) |
| Immunogen: | ABCC5. |
| Ordering Information | ||||
| Pierce Anti-ABCC5 Monoclonal Antibody | ||||
| Product Number | Pkg. Size | Price | Purchase | |
| MA1-35684 | 1 ml | $531.00 | ||
| Storage: | -20º C, Avoid Freeze/Thaw Cycles |
| Form: | 1 ml serum-free tissue cµlture supernatant (250 µg immunoglobµlin/ml) in 0.7% BSA and 0.1% sodium azide. |
| Applications | Dilution |
| Flow Cytometry (FACS) | Assay dependent. |
| Immunocytochemistry (ICC) | 1:20 |
| Immunohistochemistry (Frozen) (IHC (F)) | 1:20 |
| Western Blot (WB) | 1:20 |
| Product Specific Information |
| MA1-35684 detects ABCC5 in human samples. MA1-35684 has been successfully used in immunohistochemistry (frozen), flow cytometry, western blotting and immunocytochemistry applications. The MA1-35684 immunogen is from ABCC5. |
| General Information |
| ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. This protein functions in the cellular export of its substrate, cyclic nucleotides. This export contributes to the degradation of phosphodiesterases and possibly an elimination pathway for cyclic nucleotides. Studies show that this protein provides resistance to thiopurine anticancer drugs, 6-mercatopurine and thioguanine, and the anti-HIV drug 9-(2-phosphonylmethoxyethyl)adenine. This protein may be involved in resistance to thiopurines in acute lymphoblastic leukemia and antiretroviral nucleoside analogs in HIV-infected patients. Alternative splicing of this gene has been detected; however, the complete sequence and translation initiation site is unclear. |
(This product is for In Vitro experimental use only.)
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PO
Box 117, Rockford, IL 61105 USA |
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