Anti-Myeloperoxidase Monoclonal Antibody
| Host / Isotype: |
Mouse / IgG1 |
| Class: |
Monoclonal |
| Type: |
Antibody |
| Clone: |
266-6K1 |
| Label: |
|
| Species Reactivity: |
Human (Hu) |
| Immunogen: |
Myeloperoxidase |
|
| ELISA (ELISA) |
Assay dependent. |
| Immunohistochemistry (Frozen) (IHC (F)) |
1:10 |
| Immunoprecipitation (IP) |
Assay dependent. |
| Western Blot (WB) |
1:10 |
| Pierce Anti-Myeloperoxidase Monoclonal Antibody |
|
| Product Number |
Pkg Size |
Price |
|
|
| MA1-35670 |
1 ml |
$370.00 |
|
|
|
|
| Storage: |
4 °C |
| Form: |
1 ml filtered antibody (100 µg/ml) in PBS, 0.02% sodium azide and 0.1% BSA |
MA1-35670 detects MPO in human samples.
MA1-35670 has been successfully used in immunohistochemistry (frozen), ELISA, immunoprecipitation and western blotting applications.
The MA1-35670 immunogen is from myeloperoxidase. |
Myeloperoxidase is a hemoprotein that is abundantly expressed in neutrophils and secreted during their activation. Native Myeloperoxidase is represented as a covalently bound tetrameric complex of two glycosylated alpha chains (MW ~59 - 64 kDa) and two unglycosylated beta chains (MW ~14 kDa) with total MW ~150 kDa and theoretical pI 9.2. Traditionally Myeloperoxidase was considered as a main target of anti-neutrophil cytoplasm antibodies (ANCA), the serological markers for certain systemic vasculities e.g. periarteriitis nodosa, microscopic polyarteriitis and pulmonary eosinophilic granulomatosis (Churg-Strauss syndrome). Low to moderate anti-Myeloperoxidase autoantibody levels are also reported in rheumatoid arthritis. Recently it was shown that Myeloperoxidase participates in the initiation and progression of cardiovascular disease. It possesses potent proinflammatory properties and may contribute directly to tissue injury. Now Myeloperoxidase is under consideration as one of the most promising cardiac markers. |
No references for this product. |
This product is for In Vitro experimental use only
Printable Datasheet
