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MYELOPEROXIDASE ANTIBODIES > MYELOPEROXIDASE MONOCLONAL ANTIBODY MA1-35670
Anti-Myeloperoxidase Monoclonal Antibody
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Synonyms:
Myeloperoxidase
Entrez Gene ID:
(Human) 4353
UniProt ID:
P05164
| Details | |
| Host / Isotype: | Mouse / IgG1 |
| Class: | Monoclonal |
| Type: | Antibody |
| Clone: | 266-6K1 |
| Species Reactivity: | Human (Hu) |
| Immunogen: | Myeloperoxidase |
| Ordering Information | ||||
| Pierce Anti-Myeloperoxidase Monoclonal Antibody | ||||
| Product Number | Pkg. Size | Price | Purchase | |
| MA1-35670 | 1 ml | $370.00 | ||
| Storage: | 4º C |
| Form: | 1 ml filtered antibody (100 µg/ml) in PBS, 0.02% sodium azide and 0.1% BSA |
| Applications | Dilution |
| ELISA (ELISA) | Assay dependent. |
| Immunohistochemistry (Frozen) (IHC (F)) | 1:10 |
| Immunoprecipitation (IP) | Assay dependent. |
| Western Blot (WB) | 1:10 |
| Product Specific Information |
| MA1-35670 detects MPO in human samples. MA1-35670 has been successfully used in immunohistochemistry (frozen), ELISA, immunoprecipitation and western blotting applications. The MA1-35670 immunogen is from myeloperoxidase. |
| General Information |
| Myeloperoxidase is a hemoprotein that is abundantly expressed in neutrophils and secreted during their activation. Native Myeloperoxidase is represented as a covalently bound tetrameric complex of two glycosylated alpha chains (MW ~59 - 64 kDa) and two unglycosylated beta chains (MW ~14 kDa) with total MW ~150 kDa and theoretical pI 9.2. Traditionally Myeloperoxidase was considered as a main target of anti-neutrophil cytoplasm antibodies (ANCA), the serological markers for certain systemic vasculities e.g. periarteriitis nodosa, microscopic polyarteriitis and pulmonary eosinophilic granulomatosis (Churg-Strauss syndrome). Low to moderate anti-Myeloperoxidase autoantibody levels are also reported in rheumatoid arthritis. Recently it was shown that Myeloperoxidase participates in the initiation and progression of cardiovascular disease. It possesses potent proinflammatory properties and may contribute directly to tissue injury. Now Myeloperoxidase is under consideration as one of the most promising cardiac markers. |
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Immunohistochemistry with anti-Myeloperoxidase Monoclonal Antibody [266-6K1] (MA1-35670)
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(This product is for In Vitro experimental use only.)
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Box 117, Rockford, IL 61105 USA |
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