| Details | |
| Host / Isotype: | Rat / IgG1 |
| Class: | Monoclonal |
| Type: | Antibody |
| Clone: | BXP-9 |
| Species Reactivity: | Murine (Ms) |
| Immunogen: | Fusion protein composed of the E. coli maltose binding protein andmouse bcrp protein (residues 221-394). |
| Ordering Information | ||||
| Pierce Anti-ABCG2 Monoclonal Antibody | ||||
| Product Number | Pkg. Size | Price | Purchase | |
| MA1-35032 | 1 ml | $531.00 | ||
| Storage: | -20º C, Avoid Freeze/Thaw Cycles |
| Form: | 1 ml serum-free tissue culture supernatant (250 µg immunoglobulin/ml) in 0.7% BSA and 0.1% sodium azide. |
| Applications | Dilution |
| Flow Cytometry (FACS) | Assay dependent. |
| Immunocytochemistry (ICC) | 1:20 - 1:50 |
| Immunohistochemistry (IHC) | 1:20 |
| Western Blot (WB) | 1:20 - 1:50 |
| Product Specific Information |
| MA1-35032 detects ABCG2 in mouse samples. MA1-35032 has been successfully used in immunocytochemistry, immunohistochemistry, western blotting and flow cytometry applications. The MA1-35032 immunogen is from a fusion protein containing the E coli maltose binding protein and a fragment of the mouse bcrp protein corresponding to amino acids 221-394. |
| General Information |
| The membrane-associated protein encoded by this gene is included in the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the White subfamily. Alternatively referred to as a breast cancer resistance protein, the human protein functions as a xenobiotic transporter which may play a major role in multi-drug resistance. This protein likely serves as a cellular defense mechanism in response to mitoxantrone and anthracycline exposure. |
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