Anti-DCC Monoclonal Antibody
Printable Datasheet
Synonyms:
CRC18, CRCR1, IGDCC1
Entrez Gene ID:
(Human) 1630
UniProt ID:
P43146
| Details | |
| Host / Isotype: | Mouse / IgG1 |
| Class: | Monoclonal |
| Type: | Antibody |
| Clone: | AF5 |
| Species Reactivity: | Human (Hu) |
| Immunogen: | Extracellular domain of the human DCC protein. DCC, p190, has been identified as the netrin-1 receptor. |
| Ordering Information | ||||
| Pierce Anti-DCC Monoclonal Antibody | ||||
| Product Number | Pkg. Size | Price | Purchase | |
| MA1-25883 | 50 µg | $440.00 | ||
| Storage: | -20º C, Avoid Freeze/Thaw Cycles |
| Form: | 50 µg of immunogen affinity purified antibody (0.1 mg/ml) in 0.25% gelatin, 50mM sodium phosphate with 0.1% sodium azide. |
| Applications | Dilution |
| Immunofluorescence (IF) | 1 - 5 µg/ml |
| Immunoprecipitation (IP) | Assay Dependent |
| Western Blot (WB) | 1 - 5 µg/ml |
| Product Specific Information |
| MA1-25883 detects DCC from human samples. MA1-25883 has been successfully used in immunoprecipitation, and Western blot procedures. The MA1-25883 immunogen is the extracellular domain of the human DCC protein. DCC, p190, has been identified as the netrin-1 receptor. |
| General Information |
| This gene encodes a netrin 1 receptor. The transmembrane protein is a member of the immunoglobulin superfamily of cell adhesion molecules, and mediates axon guidance of neuronal growth cones towards sources of netrin 1 ligand. The cytoplasmic tail interacts with the tyrosine kinases Src and focal adhesion kinase (FAK, also known as PTK2) to mediate axon attraction. The protein partially localizes to lipid rafts, and induces apoptosis in the absence of ligand. The protein functions as a tumor suppressor, and is frequently mutated or downregulated in colorectal cancer and esophageal carcinoma. |
(This product is for In Vitro experimental use only.)
 |
|||||||||||||
PO
Box 117, Rockford, IL 61105 USA |
 |
 |
