| Details | |
| Host / Isotype: | Mouse / IgG1 |
| Class: | Monoclonal |
| Type: | Antibody |
| Clone: | hVIN-1 |
| Species Reactivity: | Human (Hu) Murine (Ms) Rat (Rt) Canine (Ca) Bovine (Bv) Chicken (Ck) Avian (Av) Xenopus laevis (Xl) |
| Immunogen: | Purified, full length, native human protein. |
| Ordering Information | ||||
| Pierce Anti-Vinculin Monoclonal Antibody | ||||
| Product Number | Pkg. Size | Price | Purchase | |
| MA1-25018 | 200 µl | $440.00 | ||
| Storage: | -20º C, Avoid Freeze/Thaw Cycles |
| Form: | 200 µl of ascites antibody with 15 mM sodium azide. |
| Applications | Dilution |
| Immunofluorescence (IF) | 1:400 |
| Immunohistochemistry (Frozen) (IHC (F)) | Assay Dependent |
| Western Blot (WB) | Assay Dependent |
| Product Specific Information |
| MA1-25018 detects Vinculin from human, mouse, rat, Xenopus laevis, bovine, chicken, canine, and turkey samples. MA1-25018 has been successfully used in immunohistochemistry (frozen), and Western blot procedures. The MA1-25018 immunogen is purified, full length, native human protein. |
| General Information |
| Vinculin is a cytoskeletal protein associated with cell-cell and cell-matrix junctions, where it is thought to function as one of several interacting proteins involved in anchoring F-actin to the membrane. Defects in VCL are the cause of cardiomyopathy dilated type 1W. Dilated cardiomyopathy is a disorder characterized by ventricular dilation and impaired systolic function, resulting in congestive heart failure and arrhythmia. Multiple alternatively spliced transcript variants have been found for this gene, but the biological validity of some variants has not been determined. |
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