Anti-DAXX Monoclonal Antibody
Printable Datasheet
Synonyms:
DADB-159G18.9, BING2, DAP6, EAP1, MGC126245, MGC126246
Entrez Gene ID:
(Human) 1616
UniProt ID:
Q9UER7
| Details | |
| Host / Isotype: | Mouse / IgG1 |
| Class: | Monoclonal |
| Type: | Antibody |
| Clone: | DAXX-03 |
| Species Reactivity: | Human (Hu) |
| Immunogen: | His6-tagged protein corresponding to amino acids 580-740 of human Daxx. |
| Ordering Information | ||||
| Pierce Anti-DAXX Monoclonal Antibody | ||||
| Product Number | Pkg. Size | Price | Purchase | |
| MA1-19731 | 100 µg | $285.00 | ||
| Storage: | -20º C, Avoid Freeze/Thaw Cycles |
| Form: | 100 µg of protein-A affinity chromatography purified (>95% by SDS-PAGE) antibody (1 mg/ml) in PBS with 15 mM sodium azide (pH 7.4). |
| Applications | Dilution |
| Immunocytochemistry (ICC) | Assay Dependent |
| Immunoprecipitation (IP) | Assay Dependent |
| Western Blot (WB) | 2 µg/ml |
| Product Specific Information |
| MA1-19731 detects Daxx from human samples. MA1-19731 has been successfully used in immunoprecipitation, Western blot, and immunocytochemistry applications. The MA1-19731 immunogen is His6-tagged protein corresponding to amino acids 580-740 of human Daxx. |
| General Information |
| Daxx is an apoptosis-modulating death-domain associated protein with functions in transcriptional regulation. Daxx functions bot in cytoplasm, where it interacts with Fas, and in nucleus (residing in PML oncogenic domains), where it is involved in SUMO-dependent regulation of transcription and subnuclear compartmentalization. Daxx senzitizes the cells to apoptosis, but on the other hand, this protein may also serve in preventing apoptosis in the early embryo. Even regarding the transcription, Daxx can serve both as a corepressor and a coactivator. During ischemic stress, Daxx translocates from the nucleus to the cytoplasm, where in regulates sodium hydrogen exchanger isoform 1 (NHE1). |
(This product is for In Vitro experimental use only.)
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Box 117, Rockford, IL 61105 USA |
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