Anti-ABCA7 Monoclonal Antibody
| Host / Isotype: |
Mouse / IgG2a, kappa |
| Class: |
Monoclonal |
| Type: |
Antibody |
| Clone: |
7A1-144 |
| Label: |
|
| Species Reactivity: |
Murine (Ms) |
| Immunogen: |
Mouse ABCA7 stably-transfected HeLa cells. |
|
| Flow Cytometry (FACS) |
1:500 |
| Western Blot (WB) |
1:500 |
| Pierce Anti-ABCA7 Monoclonal Antibody |
|
| Product Number |
Pkg Size |
Price |
|
|
| MA1-16935 |
100 µl |
$285.00 |
|
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| Storage: |
-20º C, Avoid Freeze/Thaw Cycles |
| Form: |
100 µl of protein G purified rat ascites in Tris-glycice with 150mM NaCl containing 0.05% sodium azide. |
MA1-16935 detects ABCA7 protein in mouse samples.
MA1-16935 has been successfully used in flow cytometry and Western blot procedures. By Western blot, MA1-16935 is specific for the ~240 kDa ABCA7 protein.
MA1-16935 immunogen is mouse ABCA7 stably-transfected HeLa cells.
Figure 1 shows FACS analysis of 6C (red) (negative control HeLa cells) and A7 (blue) (ABCA7 expressing HeLa cells) using MA1-16935 at a 1:2,000 dilution.
Figure 2 shows a Western blot detection of ABCA7 using MA1-16935 at various dilutions in ABCA7 transfected HeLa lysates. |
Mutations in the ABCA1 gene (ATP-binding cassette transporter 1) have been reported in Tangier disease (TD). TD is an autosomal recessive disorder characterized by an absence of plasma HDL, cholesterol ester depositing in the reticulo-endothelial system and deviations in cellular lipid trafficking. ABCA1 mediates the apo-A1 associated export of cholesterol and phospholipids from the cell. It is expressed on the plasma membrane and the Golgi complex, and is regulated by cholesterol flux. Regulation of the cholesterol flux between HDL and macrophages is competitive between ABCA1 and SR-BI. |
 
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No references for this product. |
This product is for In Vitro experimental use only
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